Neuroplasticity in the auditory brainstem : from physiology to the drug therapy / Angelo Salami. editor.

Format:

Book

Contributor:

Salami, Angelo.

Series:

Neurology--laboratory and clinical research development series.

Pharmacology-research, safety testing, and regulation series.

Neurology : laboratory and clinical research developments

Pharmacology : research, safety testing and regulation

Language:

English

Subjects (All):

Auditory pathways.

Neuroplasticity.

Brain stem.

Cochlear implants.

Physical Description:

1 online resource (191 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2011.

Language Note:

English

Summary:

According to the theory of neuroplasticity, thinking, learning, acting and hearing can change both the brain's physical structure and functional organisation according to the peripheral stimuli. This book reviews the knowledge on the neuroplasticity in the auditory brainstem: from physiology to the drug therapy.

Contents:

Intro

NEUROPLASTICITY IN THE AUDITORY BRAINSTEM: FROM PHYSIOLOGY TO THE DRUG THERAPY

Contents

Introduction

Chapter I Anatomy of the Auditory Pathway

Abstract

1. The Inner Ear

2. The Auditory Nerve

3. The Central Auditory Pathway

3.1. The Cochlear Nuclear Complex (CNC)

3.2. Superior Olivary Complex (SOC)

3.3. Inferior Colliculus (IC)

4. Central Pathways and Cortical Projections

5. The Primary Auditory Cortex (PAC, AI)

6. Efferent Projections

6.1. From the AC to both the MBG and IC

6.2. From the IC to both Cochlear Nuclei (CN) and the SOC

6.3. From the SOC to the Hair Cells

References

Chapter II Phsyiology of the Central Auditory System

Central Auditory Processing Strategies

Spontaneous Rat

Intensity Coding

Frequency Coding

Temporal Coding

Sound Localization

Complex Stimuli

Variation in the Physiology of the Normal Central Auditory Pathway

Anesthesia

Development

Attention

Conclusions

Acknowledgments

Chapter III Neurobiology of Age Related Hearing Loss

Neurobiology

Neurotrophins

Mitochondrial Modifications

Other Mechanisms of Mitochondrial Damage are Related to Lipid Oxidation and Protein Oxidation

Discussion

Conclusion

Chapter IV Neuroplasticity in the Auditory System after Hearing Loss

Molecular Mechanisms of Neuroplasticity

Neuroplasticity and Auditory System

Neurons, Growth Cones and Neuroplasticity

Neuroplasticity and Experimental Deafness by Cochlear Induced Lesion

1. First Phase: Acute Cochlear Nuclei Degeneration [5,6]

2. Second Phase: Stabilization of Lesions and Neuroplasticity.

3. Third Phase: Neuroplasticity and CN Reorganization

Chapter V Hearing Loss and Balance Dysfunction in Children

Sensorineural Hearing Loss

1. Balance and Vestibular Dysfunction in SHNL

2. Cochlear Implantation and Vestibular Function

Conductive Hearing Loss

Rehabilitation of Balance and Motor Skills in the Hearing Impaired Child

Chapter VI The Effect of Brain Plasticity on the Results of Cochlear Implantation

1. The Importance of Brain Research in Deaf Patients

2. Cross-Modal Plasticity

3. Method Used to Evaluate Human Brain Function

4. PET Studies in Deaf Patients

4.1. Cortical Metabolism in Prelingually Deaf Children

4.2. Cortical Metabolism in Postlingually Deaf Adults

4.3. The Association between Cortical Metabolism and Post-implant Speech Perception in the Prelingually Deaf

4.4. Changes in Cortical Metabolism after Cochlear Implantation

5. Changes in Cognitive Function in Deaf Patients

6. Studies Using Deaf Animal Models

6.1. Changes in Auditory Cortex Metabolism in the White Rat Model

6.2. Molecular Changes in the Auditory Cortex of a Deaf White Rat Model

6.3. Electrophysiologic and Metabolic Changes in the Auditory Cortex in a Deaf Cat Model

7. Summary and Future Research Directions

Chapter VII Pharmacology of New Drugs Used to Improve the Neuroplasticity of the Central Auditory Pathway

Coenzyme Q10

Basic Pharmacology and Toxicity

Coenzyme Q10 and Neuroprotection

Experimental and Clinical Data

Q-TER®: A Water-soluble Formulation of CoQ10

Citicoline

Synthesis of Membrane Phospholipids

Neurotransmitter Production

Basic Pharmacology and Toxicity.

Experimental and Clinical Data

Chapter VIII New Drugs to Improve the Neuroplasticity of the Central Auditory Pathway

Antioxidant Agents

Methods

Results

Chapter IX Central Auditory System Neuroplasticity and Hippocampal Neurogenesis following Cochlear Insults

Salicylate-Induced Cochlear Insult

Acute Salicylate Exposure

Chronic Salicylate Exposure

Carboplatin-induced Ototoxicity

Acoustic Overstimulation

Index

Blank Page.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61122-383-0

OCLC:

726743253