Recent research developments in foldamer chemistry / G.V.M. Sharma and A.C. Kunwar ; Y.V.D. Nageswar, editor.

Format:

Book

Author/Creator:

Sharma, G. V. M.

Contributor:

Kunwar, A. C.

Nageswar, Y. V. D.

Series:

Biochemistry research trends series.

Protein biochemistry, synthesis, structure, and cellular functions series.

Biochemistry research trends

Protein biochemistry, synthesis, structure and cellular functions

Language:

English

Subjects (All):

Peptides--Synthesis.

Peptides.

Physical Description:

1 online resource (213 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2012.

Language Note:

English

Summary:

The book presents details on the 'aliphatic foldamers', with a special emphasis on the peptides with - homogeneous backbones (a- and -peptides), peptides with heterogeneous backbones (from alternating -, -, a-, - and -amino acids), peptides with backbone modifications (aminoxy-, hydrazine- and ureido peptides), peptides from sugar amino acids and methods for conformational analysis. The material presented in the book is useful for the research and student community to usher in a sustained propagation of this active area of research on 'foldamers'.

Contents:

Intro

RECENT RESEARCH DEVELOPMENTS IN FOLDAMER CHEMISTRY

LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA

CONTENTS

PREFACE

Chapter 1 INTRODUCTION

PEPTIDE SYNTHESIS

PEPTIDE SECONDARY STRUCTURE

BACKBONE DIHEDRAL ANGLES AND RAMACHANDRAN PLOT

DETERMINATION OF PEPTIDE CONFORMATION

CONFORMATIONAL PROPERTIES IN a-PEPTIDES

SUPER-SECONDARY STRUCTURES (MOTIFS)

CONFORMATIONS IN β -PEPTIDES

β-SHEETLIKE CONFORMATION

INTRODUCTION TO y-PEPTIDES

REFERENCES

Chapter 2 FOLDAMERS WITH HOMOGENEOUS BACKBONES

SECTION A: y-PEPTIDES

SECTION B: δ-PEPTIDES

Chapter 3 FOLDAMERS WITH HETEROGENEOUS BACKBONES

SECTION A: α/β -PEPTIDES

SECTION B: α/γ α/δ α/ε- AND OTHER PEPTIDES

Chapter 4 FOLDAMERS WITH BACKBONE MODIFICATION

SECTION A: PEPTIDES CONTAINING AMINOXY ACIDS

SECTION B: PEPTIDES CONTAINING HYDRAZINE ACIDS

SECTION C: PEPTIDES CONTAINING UREA BACKBONE

Chapter 5 FOLDAMERS WITH SUGAR AMINO ACIDS (SAAS)

Chapter 6 ANALYTICAL TECHNIQUES FOR FOLDAMER CHARACTERIZATION

INTRODUCTION

DETERMINATION OF PEPTIDE CONFORMATION USING NMR SPECTROSCOPY

RESONANCE ASSIGNMENT

CHEMICAL SHIFTS

Signatures in the nOe Experiments

RESTRAINTS GENERATION

Distance Restraints

Angle Restraints

Information on H-bonds

Reduced Dipolar Couplings (RDC)

SOLID STATE NMR

PEPTIDE AGGREGATION

MOLECULAR DYNAMIC (MD) CALCULATIONS

CIRCULAR DICHROISM (CD) SPECTROSCOPY

X-RAY DIFFRACTION

GROWING SINGLE CRYSTAL

STRUCTURE FROM POWDER DIFFRACTION PATTERN

IR SPECTROSCOPY

ABOUT THE AUTHORS

INDEX.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-61942-137-2

OCLC:

923669405