Chemokines : types, functions, and structural characteristics / Keith J. Walker, editor.

Format:

Book

Contributor:

Walker, Keith J.

Series:

Cell Biology Research Progress

Cell biology research progress

Language:

English

Subjects (All):

Chemokines.

Immunology.

Physical Description:

1 online resource (197 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2011.

Language Note:

English

Summary:

Chemokines are a family of small cytokines, or proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. The major role of chemokines is to act as a chemoattractant to guide the migration of cells. Cells that are attracted by chemokines follow a signal of increasing chemokine concentration towards the source of the chemokine. This book presents current research in the study of chemokines from across the globe, including such topics as development of chemokine network targeting agents for the treatment of allergic, autoimmune and inflammatory diseases and cancers; chemokines in teleost fish species; gene regulation of chemokines in response to bacterial enterotoxins; and the role of chemokines in colorectal cancer and metastasis.

Contents:

""CHEMOKINES: TYPES, FUNCTIONS AND STRUCTURAL CHARACTERISTICS ""; ""CHEMOKINES: TYPES, FUNCTIONS AND STRUCTURAL CHARACTERISTICS ""; ""Contents ""; ""Preface""; ""Mechanisms and Development of Chemokine Network Targeting Agents for the Treatment of Allergic, Autoimmune and Inflammatory Diseases and Cancers ""; ""Abstract ""; ""Introduction ""; ""The Question of Redundancy ""; ""Selection of Chemokine Targets""; ""Chemokine Receptor Antagonism ""; ""Current Status ""; ""Biology of GAGs in Chemokine Biology and Leukocyte Trafficking ""; ""Glycosaminoglycan Structure, Function and Diversity ""

""Specificity in Chemokine-GAG Interactions and GAG-Induced Oligomerization """"Chemokine Oligomerization Controls Cell Surface Presentation ""; ""Non-GAG Binding and Improved GAG Binding Chemokine Mutants ""; ""Double Negative Knockout Chemokine Mutants with Improved GAG Affinity and Ablated Chemokine Receptor Binding Potential""; ""Other Novel Therapeutic Approaches ""; ""Broad-Spectrum Chemokine Inhibitors (BCSIs) ""; ""Spiegelmers ""; ""Bindarit ""; ""Chemokine-Targeted Cell Depleting Agents ""; ""Chemokines and Gene Therapy""; ""Gene Therapy Vectors and Delivery ""

""Direct Gene Delivery in vivo """"Immune Effector Cell Recruitment ""; ""Regulation of Angiogenesis ""; ""Inhibition of Endogenous Chemokine Ligands ""; ""Stem Cell Therapy ""; ""RNA Interference ""; ""Background ""; ""RNAi Developmental Hurdles ""; ""RNAi Studies in Cancer and Metastasis ""; ""RNAi Studies in Viral Infection ""; ""RNAi Studies in Inflammatory Diseases""; ""Conclusion ""; ""Acknowledgments ""; ""References ""; ""How Chemokines Implicate in T Lymphocyte Biology ""; ""Abstract ""; ""Introduction ""

""The Role of Chemokines and Chemokine Receptors on Gamma Delta Development in the Thymus """"Chemokine Guidance of Tissue-Specific Homing and Recirculation of T Lymphocytes ""; ""Migration of T Lymphocytes into Tissue during Inflammation""; ""Chemokine Receptors as Markers of T Lymphocyte Phenotype ""; ""Production of Chemokines by T Lymphocytes in Inflammation & Infection ""; ""Concluding Remarks ""; ""Footnote ""; ""References ""; ""Chemokines in Teleost Fish Species""; ""Abstract ""; ""Introduction ""; ""Zebrafish Chemokines""; ""Rainbow Trout Chemokines ""

""Catfish Chemokines """"Chemokines in Other Fish Species ""; ""Chemokine Receptors ""; ""Conclusion ""; ""Acknowledgments ""; ""References""; ""Gene Regulation and Expression of Chemokines in Response to Bacterial Enterotoxins ""; ""Abstract ""; ""Introduction ""; ""B. Fragilis Enterotoxin Stimulation Up-Regulates Cxc Chemokines in Intestinal Epithelial Cells ""; ""C. Difficile Enterotoxin (Toxin A) Up-Regulates CXC and CC Chemokines in Intestinal Epithelial Cells ""

""NF- B Activation Pathway in Intestinal Epithelial cells is a Major Regulator of Chemokine Gene Expression in Intestinal Epithelial cells Stimulated With B. Fragilis Enterotoxin and C. Difficile Toxin A ""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record; title from PDF title page, viewed (07/17/2020).

ISBN:

1-61761-171-9

OCLC:

923657739