Superparamagnetic iron oxide nanoparticles : synthesis, surface engineering, cytotoxicity and biomedical applications / Morteza Mahmoudi ... [et al.].

Format:

Book

Contributor:

Mahmoudi, Morteza, 1979-

Series:

Nanotechnology science and technology series.

Nanotechnology science and technology

Language:

English

Subjects (All):

Nanomedicine.

Ferric oxide--Magnetic properties.

Ferric oxide.

Nanoparticles.

Physical Description:

1 online resource (239 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2011.

Language Note:

English

Summary:

Interest in nanoparticles arise from the fact that the chemical, mechanical, electrical, optical, magnetic, electro-optical and magneto-optical properties of these particles are different from their bulk properties and depend on the particle size. This book reviews research on the various components of superparamagnetic iron oxide nanoparticles.

Contents:

Intro

SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES: SYNTHESIS, SURFACE ENGINEERING, CYTOTOXICITY AND BIOMEDICAL APPLICATIONS

LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA

DEDICATION

ABOUT THE AUTHORS

CONTENTS

PREFACE

Chapter 1 INTRODUCTORY TO THE BOOK

1.1. SEMICONDUCTING NANOPARTICLES

1.2. IRON OXIDE NANOPARTICLES

1.3. BIOMINERALIZATION

1.4. TYPES OF MAGNETIC IRON OXIDES

1.5. SYNTHESIS OF SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONS): CHEMICAL COPRECIPITATION

1.6. DESIGN OF EXPERIMENTS (DOE) FOR SYNTHESIS OF SPIONS

REFERENCES

Chapter 2 SYNTHESIS OF SPIONS

2.1. NUCLEATION OF NANOPARTICLES

2.2. SYNTHESIS METHODS

2.2.1. Chemical Methods

2.2.1.1. Co-precipitation

2.2.1.2. Microemulsions

2.2.1.3. Hydrothermal

2.2.1.4. Thermal Decomposition

2.2.1.5. Sol-gel

2.2.1.6. Polyol

2.2.1.7. Sonochemical

2.2.1.8. Electrochemical Deposition

2.2.2. Physical Methods

2.2.2.1. Flow Injection

2.2.2.2. Aerosol/Vapor

2.2.2.3. Pulsed Laser Ablation

2.2.2.4. Laser Induced Pyrolysis

2.2.2.5. Powder Ball Milling

2.2.3. Biological/ Bio-mineralization

Chapter 3 APPLICATION OF STATISTICAL TECHNIQUES

3.1. THE TWO SAMPLE T-TEST

3.2. HYPOTHESIS TESTING FOR OUTLIER DETECTION - GRUBBS' TEST

3.3. DESIGN OF EXPERIMENTS

Remark: How to Perform the Analysis with More than Two Factors, Two Levels?

3.3.1. Checking Model Assumptions: Effect of Potentially Outlying Observations

Chapter 4 COATINGS OF SPIONS

4.1. COLLOIDAL STABILITY OF SPIONS

4.2. POLYMERIC COATING

4.2.1. Polyethylene Glycol

4.2.2. Polyethylene Glycol Fumarate

4.2.3. Polyvinyl Alcohol

4.2.4. Polyacrylic Acid.

4.2.5. Poly(N-isopropylacrylamide)

4.2.6. Dextran

4.2.7. Poly(D,L-lactide)

4.2.8. Poly(D,L-lactide-co-glycolide)

4.2.9. Alginate

4.2.10. Chitosan and Polyethylenimine

4.3. NON-POLYMERIC COATING

4.3.1. Gold

4.3.2. Silica

4.4. FUNCTIONALIZATION OF SPIONS

Chapter 5 CYTOTOXICITY OF SPIONS

5.1. BIOCOMPATIBILITY VERSUS TOXICITY

5.1.1. Biocompatibility

5.1.2. Cytotoxicity

5.2. IN VITRO TOXICITY ASSAYS

5.2.1. Metabolic Activity

5.2.1.1. MTT Assay

5.2.1.1.1. Modification of MTT Method

5.2.1.2. MTS and XTT Assays

5.2.1.2.1. MTS Assay

5.2.1.2.2. XTT Assay

5.2.1.3. Redox Assay

5.2.1.4. Adenosine Triphosphate Assay

5.12.1.5. Cytochrome C Assay

5.2.1.6. Nitroblue Tetrazolium (NBT) Assay

5.2.1.7. WST Assay

5.2.2. Membrane Integrity

5.2.2.1. LDH Assay

5.2.2.2. The Calcein AM, Live/Dead and Ethidium Homodimer Assay

5.2.2.3. Dye Assays

5.2.2.3.1. Erythrosine B (EB) Assay

5.2.2.3.2. Propidium Iodide (PI) Assay

5.2.2.3.3. Neutral Red (NR) Assay

5.2.2.3.4. Bromodeoxyuridine (BrdU) Assay

5.2.2.3.5. Trypan Blue (TB) Assay

5.2.2.3.6. DNA Hoechst Assay

5.2.2.3.7. Other Dye Assays

5.2.3. Cell Proliferation Assay

5.2.3.1. Cell Cycle Assay

5.2.3.2. [3H] Thymidine Incorporation Assay

5.2.4. Apoptosis Detection

5.2.4.1. Flow Cytometry

5.2.4.2. Comet Assay

5.3. IN VIVO TOXICITY

5.4. PHARMACOKINETICS AND BIODISTRIBUTION

Chapter 6 APPLICATION OF SPIONS*

6.1. SPIONS AS MAGNETIC RESONANCE IMAGING CONTRAST AGENT

Introduction

Paramagnetic Agents

Superparamagnetic Agents

Current Clinical Use of (U)SPIONs as Contrast Agents

Oral Contrast Agents

Injectable Contrast Agents

Ferumoxides (Feridex I.V./Endorem)

Ferucarbotran/SHU555A (Resovist/Cliavist)

Ferumoxtran-10 (USPIO) (Combidex/Senerem).

PEG-feron (Feruglose/Clariscan)

Ferucarbotran (USPIO)/SHU555C (Supravist)

Ferumoxytol (USPIO) (Feraheme)

6.2. SPIONS FOR MAGNETIC LABELING OF CELLS

SPIONs and its Modification for Labeling

Transfection Agents Mediated Modification of SPIONs for Cell Labeling

Optimization of Cell Labeling with Simple Incubation

Assay to Determine the Toxicity of Labeling

6.3. SPIONS AND MAGNETICALLY LABELED CELLS FOR MULTIMODAL REGIMENS

SPIONs for Multimodal Imaging

Cells for Multimodal Imaging

6.4. SPIONS AS DRUG DELIVERY VEHICLES

Active Targeting Using Ligand Substrate Mechanisms, Antigen-Antibody or Receptors

Enhanced Permeability Retention (EPR) Effect

Convection-Enhanced Delivery

Magnet Activated Delivery

Drug Delivery by Direct Injection

6.5. SPIONS FOR HYPERTHERMIA TREATMENT

6.6. SPIONS FOR ENHANCED TRANSFECTION OF DNA (MAGNETOFECTION)

6.7. SPIONS FOR CELL/PROTEIN SEPARATION

6.8. SPIONS AS CATALYST

6.9. SPIONS FOR TISSUE REPAIR

INDEX.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61728-631-1

OCLC:

782905619