Stem cells : cellular and drug therapies. Volume 1 / Philippe Taupin.

Format:

Book

Contributor:

Taupin, Philippe.

Series:

Stem cells--laboratory and clinical research series.

Stem cells - laboratory and clinical research, 2159-8738

Stem cells : cellular and drug therapies ; v. 1

Language:

English

Subjects (All):

Stem cells.

Stem cells--Therapeutic use.

Physical Description:

1 online resource (220 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, Inc., 2011.

Language Note:

English

Summary:

Stem cells are the building blocks of the body. Therefore, stem cell research is as important for our understanding the physio- and pathology of the body, as it is for understanding of development and therapy, including for the nervous system. This book provides an overview and analysis of developments in stem cell research and therapy.

Contents:

Intro

STEM CELLS: CELLULAR AND DRUG THERAPIES (VOLUME 1)

STEM CELLS:CELLULAR AND DRUG THERAPIES(VOLUME 1)

Library of Congress Cataloging-in-Publication Data

Contents

Preface

Introduction

Acknowledgments

References

Chapter I: Adult Neurogenesis in Mammals

Abstract

1. Introduction

2. Labeling Newly Generated Neuronal Cells in the Adult Brain

3. Modulation of Adult Neurogenesis

4. Function of Adult Neurogenesis

5. Contribution of Adult Neurogenesis to CNS Physiopathology

6. Neurogenesis in the Adult Human Brain: Particularities and Implications

Conclusion

Chapter II: Protocols for Studying Adult Neurogenesis: Insights and Recent Developments

Executive Summary

2. BrdU Labeling, Cell Proliferation, Migration, Birthdating, and Fate Determination

3. Controversies and Debates over the Use of BrdU for Studying Adult Neurogenesis

4. Alternative Strategies to Study Adult Neurogenesis

5. BrdU Labeling, Cell Kinetic and Cell Lineage Relative to Proliferative History

Chapter III: Adult Neural Stem Cells, Neurogenic Niches and Cellular Therapy

Adult Neurogenesis and NSCs

Neurogenic Niches

Broader Potential of Adult Stem Cells

Cellular Therapy

Chapter IV: The Therapeutic Potential of Adult Neural Stem Cells

2. Adult Neurogenesis and Neural Stem Cells

3. Physiology of Newly Generated Neuronal Cells in the Adult Brain

4. Adult-Derived Neural Progenitor and Stem Cells

5. Cell-Based Therapies for the Treatment of CNS Diseases and Injuries

Author's Note

Chapter V: Human Neural Progenitor and Stem Cells.

Abstract

2. Chemistry

3. Biology and Action

4. Expert Opinion

Chapter VI: Adult Neurogenesis Pharmacology in Neurological Diseases and Disorders

Key Issues

Neurogenesis in the Adult Brain

Neurogenesis in Neurological Diseases and Disorders

Neurogenesis and the Etiology of Neurological Diseases and Disorders

Pharmacology of Adult Neurogenesis

Discussion

Expert Commentary and Five-Year View

Financial and Competing Interests Disclosure

Chapter VII: Characterization and Isolation of Synapses of Newly Generated Neuronal Cells of the Adult Hippocampus at Early Stages of Neurogenesis

Materials and Methods

Results

Chapter VIII: Adult Neurogenesis and Neural Stem Cells as a Model for the Discovery and Development of Novel Drugs

2. Adult Neurogenesis and Drugs to Treat Neurological Diseases and Disorders

3. Expert Opinion

Declaration of Interest

Bibliography

Chapter IX: Neurogenic Drugs and Compounds

Recent Patents on Compounds and Drugs Modulating Neurogenesis in the Adult Brain

Apigenin and Related Compounds

Current and Future Developments

Conflict of Interest

Chapter X: Magnetic Resonance Imaging for Monitoring Neurogenesis in the Adult Hippocampus

Chapter XI: Transplantation of Cord Blood Stem Cells for Treating Hematologic Diseases and Strategies to Improve Engraftment

HSCs and Cord Blood Stem Cells.

Selectins and the Homing of HSCs

Transplantation of Cord Blood Stem Cells for the Treatment of Hematologic Diseases

Strategies to Improve the Outcome of CB Transplantation for the Treatment of Hematologic Diseases

Future Perspectives

Chapter XII: Transplantation of Two Populations of Stem Cells to Improve Engraftment

2. Methods

Chapter XIII: ADA-Transduced Hematopoietic Stem Cell Therapy for ADA-SCID

Summary

2. Synthesis and SAR

3. Preclinical Development

4. Metabolism and Pharmacokinetics

5. Toxicity

6. Clinical Development

7. Side Effects and Contraindications

8. Patent Summary

9. Current Opinion

10. Development History

11. Literature Classifications

Chapter XIV: Adult Periodontal-Derived Neural Progenitor and Stem Cells

Conclusion 1. Stem Cells from Non-Viable Versus Post-Mortem Tissues

Conclusion 2. Ex Vivo Fucosylation to Improve the Engraftment Capability and Therapeutic Potential of Human Cord Blood Stem Cells

Index.

Notes:

"Nova biomedical."

Includes bibliographical references and index.

ISBN:

1-62100-996-3

OCLC:

777814586