New frontiers in chemical biology : enabling drug discovery / edited by Mark E. Bunnage.

Format:

Book

Contributor:

Bunnage, Mark E.

Royal Society of Chemistry (Great Britain)

Series:

RSC drug discovery series ; 5.

RSC drug discovery series, 2041-3203 ; no. 5

Language:

English

Subjects (All):

Drug development.

Biochemistry.

Physical Description:

1 online resource (329 p.)

Edition:

1st ed.

Place of Publication:

Cambridge : RSC Pub., c2011.

Language Note:

English

Summary:

Despite ever-increasing investment in biomedical research, there has been a significant decline in the number of new drug approvals in recent years. In an effort to improve productivity, the drug discovery community has increasingly looked to biotherapeutics such as antibodies, vaccines, nucleic acids, and peptides. Chemical biology is an emerging field at the interface between chemistry and biology. It utilises the tools and techniques of chemical synthesis to study and influence biological systems. Recent developments in this area have great potential in addressing the productivity challenge

Contents:

The chemical genetic approach : the interrogation of biological mechanisms with small molecule probes / Martin Fisher and Adam Nelson

Applications for activity-based probes in drug discovery / L.E. Edgington and M. Bogyo

Targeted intracellular protein degradation as a potential therapeutic strategy / A.R. Schneekloth and C.M. Crews

Chemical biology of stem cell modulation / Stephen G. Davies and Angela J. Russell

Chemical biology of histone modifications / Nathan R. Rose, Christopher J. Schofield and Tom D. Heightman

Chemologics / Lyn H. Jones

Antibody-drug conjugates in oncology / Philip R. Hamann and Russell G. Dushin

Drug discovery by DNA-encoded libraries / Yizhou Li, Zheng Zhu and Xiaoyu Li.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9781849732178

1849732175

OCLC:

642690095