Probability models for DNA sequence evolution / Richard Durrett.

Format:

Book

Author/Creator:

Durrett, Richard, 1951-

Series:

Springer series in statistics. Probability and its applications.

Probability and its applications

Language:

English

Subjects (All):

Evolutionary genetics--Statistical methods.

Evolutionary genetics.

Nucleotide sequence--Statistical methods.

Nucleotide sequence.

Probabilities.

Variation (Biology)--Statistical methods.

Variation (Biology).

Physical Description:

1 online resource (441 pages)

Edition:

2nd ed.

Place of Publication:

New York : Springer, c2008.

Language Note:

English

Summary:

How is genetic variability shaped by natural selection, demographic factors, and random genetic drift? To approach this question, we introduce and analyze a number of probability models beginning with the basics, and ending at the frontiers of current research. Throughout the book, the theory is developed in close connection with examples from the biology literature that illustrate the use of these results. Along the way, there are many numerical examples and graphs to illustrate the conclusions. This is the second edition and is twice the size of the first one. The material on recombination and the stepping stone model have been greatly expanded, there are many results form the last five years, and two new chapters on diffusion processes develop that viewpoint. This book is written for mathematicians and for biologists alike. No previous knowledge of concepts from biology is assumed, and only a basic knowledge of probability, including some familiarity with Markov chains and Poisson processes. The book has been restructured into a large number of subsections and written in a theorem-proof style, to more clearly highlight the main results and allow readers to find the results they need and to skip the proofs if they desire. Rick Durrett received his Ph.D. in operations research from Stanford University in 1976. He taught in the UCLA mathematics department before coming to Cornell in 1985. He is the author of eight books and 160 research papers, most of which concern the use of probability models in genetics and ecology. He is the academic father of 39 Ph.D. students and was recently elected to the National Academy of Sciences.

Contents:

Basic Models

Estimation and Hypothesis Testing

Recombination

Population Complications

Stepping Stone Model

Natural Selection

Diffusion Processes

Multidimensional Diffusions

Genome Rearrangement.

Notes:

Description based upon print version of record.

Includes bibliographical references (p. [399]-426)and index.

ISBN:

1-281-95423-3

9786611954239

0-387-78169-2

OCLC:

317883343