Drug design : cutting edge approaches / editor, Darren R. Flower.

Format:

Book

Contributor:

Flower, Darren R.

Series:

Special publication (Royal Society of Chemistry (Great Britain)) ; 279.

Special publication ; no. 279

Language:

English

Subjects (All):

Drugs--Design--Congresses.

Drugs.

Drugs--Design--Mathematical models--Congresses.

Artificial intelligence--Medical applications--Congresses.

Artificial intelligence.

Drugs--Research--Methodology--Congresses.

Physical Description:

1 online resource (x, 192 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Cambridge : Royal Society of Chemistry, 2002.

Language Note:

English

Summary:

Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets.Providing details of state-of-the-art research, Drug Design: Cutting Edge Approac

Contents:

CONTENTS; Molecular Informatics: Sharpening Drug Design's Cutting Edge; High-Throughput X-Ray Crystallography for Drug Discovery; Trawling the Genome for G Protein-coupled Receptors: the Importance of Integrating Bioinformatic Approaches; Virtual Screening of Virtual Libraries - an Efficient Strategy for LeadGeneration; Virtual Techniques for Lead Optimisation; The Impact of Physical Organic Chemistry on the Control of Drug-likeProperties; Mutagenesis and Modelling Highlight the Critical Nature of theTM2-loop-TM3 Region of Biogenic Amine GPCRS; Computational Vaccine Design; Subject Index

Notes:

"Proceedings of the meeting on Cutting Edge Approaches to Drug Design held on 13 March 2001 at the Scientific Societies Lecture Theatre, London, UK"--T.p. verso.

Includes bibliographical references and index.

ISBN:

9781847550705

1847550703

9781601190277

1601190271

OCLC:

843641090