Ocular transporters in ophthalmic diseases and drug delivery / edited by Joyce Tombran-Tink, Colin J. Barnstable.

Format:

Book

Contributor:

Barnstable, Colin J.

Tombran-Tink, Joyce.

Series:

Ophthalmology research.

Ophthalmology research

Language:

English

Subjects (All):

Biological transport.

Drug targeting.

Eye--Diseases.

Eye.

Eye--Physiology.

Physical Description:

1 online resource (453 p.)

Edition:

1st ed. 2008.

Place of Publication:

Totowa, N.J. : Humana Press, c2008.

Language Note:

English

Summary:

This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye. Ocular Transporters in Ophthalmic Diseases and Drug Delivery is the first text book in this field and offers up-to-date information to clinicians, research scientists in academia, and the pharmaceutical industry. This work has clinical implications for drug development and therapeutic drug delivery, making it an invaluable resource for readers.

Contents:

Transport in the Anterior Segment

Aquaporins and Water Transport in the Cornea

Roles of Corneal Epithelial Ion Transport Mechanisms in Mediating Responses to Cytokines and Osmotic Stress

Vitamin C Transport, Delivery, and Function in the Anterior Segment of the Eye

Transporters of the Ciliary Epithelium

Mechanisms of Aqueous Humor Formation

Lens Transporters

Membrane Transporters

Lens Na+, K+-ATPase

Transport Across the Blood–Retinal Barrier

Pathophysiology of Pericyte-containing Retinal Microvessels

Molecular Mechanisms of the Inner Blood-Retinal Barrier Transporters

Transport Across the Retinal Pigment Epithelium

Regulation of Transport in the RPE

Glucose Transporters in Retinal Pigment Epithelium Development

Ca2+ Channels in the Retinal Pigment Epithelium

Taurine Transport Pathways in the Outer Retina in Relation to Aging and Disease

P-Glycoprotein Expression and Function in the Retinal Pigment Epithelium

Transporters in the Retina

The Retinal Rod NCKX1 and Cone/Ganglion Cell NCKX2 Na+/Ca2+-K+ Exchangers

Excitatory Amino Acid Transporters in the Retina

Localization and Function of Gamma Aminobutyric Acid Transporter 1 in the Retina

Genetic Variants of Ocular Transporters

Biochemical Defects Associated with Genetic Mutations in the Retina-Specific ABC Transporter, ABCR, and Macular Degenerative Diseases

Glutamate Transporters and Retinal Disease and Regulation

Glutamate Transport in Retinal Glial Cells during Diabetes

Ocular Drug Delivery

The Emerging Significance of Drug Transporters and Metabolizing Enzymes to Ophthalmic Drug Design

Barriers in Ocular Drug Delivery

Ophthalmic Applications of Nanotechnology

Vitamin C Transporters in the Retina

The Plasma Membrane Transporters and Channels of Corneal Endothelium.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-27346-5

9786611273460

1-59745-375-7

OCLC:

233972893