The immune synapse as a novel target for therapy / Luis Graca, editor.

Format:

Book

Contributor:

Graca, Luis, MD

Series:

PIR (Series)

Language:

English

Subjects (All):

Immune response--Molecular aspects.

Immune response.

Immune response--Regulation.

Synapses.

Physical Description:

1 online resource (203 p.)

Edition:

1st ed. 2008.

Place of Publication:

Basel : Birkhauser, c2008.

Language Note:

English

Summary:

The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell–APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogram the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as those targeting the lymphocyte co-receptor, costimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, LFA-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy. This volume discusses the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It is of interest to clinicians and researchers working in this area.

Contents:

The immune synapse and T cell activation: regulation by chemokines

The induction of regulatory T cells by targeting the immune synapse

Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology

Targeting CD4 for the induction of dominant tolerance

Anti-CD3: from T cell depletion to tolerance induction

Immune modulation by CD40L blockade

CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance

Adhesion molecules as therapeutic targets

E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?

FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells

Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance

From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.

Notes:

"Progress in inflammation research".

Includes bibliographical references and index.

ISBN:

1-281-14091-0

9786611140915

3-7643-8296-1

OCLC:

370727597