Statistical methods in diagnostic medicine / Xiao-Hua Zhou, Nancy A. Obuchowski, Donna K. McClish.

Format:

Book

Author/Creator:

Zhou, Xiao-Hua.

Contributor:

McClish, Donna K.

Obuchowski, Nancy A.

Series:

Wiley series in probability and statistics.

Wiley series in probability and statistics

Language:

English

Subjects (All):

Medical statistics.

Medicine--Research--Statistical methods.

Medicine.

Physical Description:

1 online resource (587 p.)

Edition:

2nd ed.

Place of Publication:

Hoboken, NJ : Wiley, 2011.

Language Note:

English

Summary:

Praise for the First Edition "" . . . the book is a valuable addition to the literature in the field, serving as a much-needed guide for both clinicians and advanced students.""-Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices

Contents:

Statistical Methods in Diagnostic Medicine; CONTENTS; List of Figures; List of Tables; 0.1 PREFACE; 0.2 ACKNOWLEDGEMENTS; PART I BASIC CONCEPTS AND METHODS; 1 Introduction; 1.1 Diagnostic Test Accuracy Studies; 1.2 Case Studies; 1.2.1 Case Study 1: Parathyroid Disease; 1.2.2 Case Study 2: Colon Cancer Detection; 1.2.3 Case Study 3: Carotid Artery Stenosis; 1.3 Software; 1.4 Topics Not Covered in This Book; 2 Measures of Diagnostic Accuracy; 2.1 Sensitivity and Specificity; 2.1.1 Basic Measures of Test Accuracy: Case Study 2

2.1.2 Diagnostic Tests with Continuous Results: The Artificial Heart Valve Example 2.1.3 Diagnostic Tests with Ordinal Results: Case Study 1; 2.1.4 Effect of Prevalence and Spectrum of Disease; 2.1.5 Analogy to α and β Statistical Errors; 2.2 Combined Measures of Sensitivity and Specificity; 2.2.1 Problems Comparing Two or More Tests: Case Study 1; 2.2.2 Probability of a Correct Test Result; 2.2.3 Odds Ratio and Youden's Index; 2.3 Receiver Operating Characteristic (ROC) Curve; 2.3.1 ROC Curves: Artificial Heart Valve and Case Study 1; 2.3.2 ROC Curve Assumption

2.3.3 Smooth, Fitted ROC Curves 2.3.4 Advantages of ROC Curves; 2.4 Area Under the ROC Curve; 2.4.1 Interpretation of the Area Under the ROC Curve; 2.4.2 Magnitudes of the Area Under the ROC Curve; 2.4.3 Area Under the ROC Curve: Case Study 1; 2.4.4 Misinterpretations of the Area Under the ROC Curve; 2.5 Sensitivity at Fixed FPR; 2.6 Partial Area Under the ROC Curve; 2.7 Likelihood Ratios; 2.7.1 Three Examples to Illustrate Likelihood Ratios; 2.7.2 Limitations of Likelihood Ratios; 2.7.3 Proper and Improper ROC Curves; 2.8 ROC Analysis When the True Diagnosis Is Not Binary

2.9 C-Statistics and Other Measures to Compare Prediction Models 2.10 Detection and Localization of Multiple Lesions; 2.11 Positive and Negative Predictive Values, Bayes Theorem, and Case Study 2; 2.11.1 Bayes Theorem; 2.12 Optimal Decision Threshold on the ROC Curve; 2.12.1 Optimal Thresholds for Maximizing Classification; 2.12.2 Optimal Threshold for Minimizing Cost; 2.12.3 Optimal Decision Threshold: Rapid Eye Movement as a Marker for Depression Example; 2.13 Interpreting the Results of Multiple Tests; 2.13.1 Parallel Testing; 2.13.2 Serial, or Sequential, Testing

3 Design of Diagnostic Accuracy Studies 3.1 Establish the Objective of the Study; 3.2 Identify the Target Patient Population; 3.3 Select a Sampling Plan for Patients; 3.3.1 Phase I: Exploratory Studies; 3.3.2 Phase II: Challenge Studies; 3.3.3 Phase III: Clinical Studies; 3.4 Select the Gold Standard; 3.5 Choose A Measure of Accuracy; 3.6 Identify Target Reader Population; 3.7 Select Sampling Plan for Readers; 3.8 Plan Data Collection; 3.8.1 Format for Test Results; 3.8.2 Data Collection for Reader Studies; 3.8.3 Reader Training; 3.9 Plan Data Analyses; 3.9.1 Statistical Hypotheses

3.9.2 Planning for Covariate Adjustment

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786613072221

9781118626047

1118626044

9781283072229

128307222X

9780470906514

0470906510

9780470906507

0470906502

OCLC:

714797065