Mass spectrometry in drug metabolism and disposition : basic principles and applications / edited by Mike S. Lee, Mingshe Zhu.

Format:

Book

Contributor:

Lee, Mike S., 1960-

Zhu, Mingshe.

Series:

Wiley UBCM ebooks.

Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods.

Wiley series on pharmaceutical science and biotechnology: practices, applications and methods

Language:

English

Subjects (All):

Drugs--Metabolism--Analysis.

Drugs.

Metabolites--Spectra.

Metabolites.

Mass spectrometry.

Physical Description:

1 online resource (776 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, c2011.

Language Note:

English

System Details:

Mode of access: World Wide Web.

Summary:

"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text"--Provided by publisher.

Contents:

(Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition

The Progression of Drug Metabolism

Common Biotransformation Reactions

Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry

Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions

Experimental Models of Drug Metabolism and Disposition

Principles of Pharmacokinetics: Predicting Human Pharmacokinetics

Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes

Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice

Theory and Instrumentation of Mass Spectrometry

Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification

Mass Spectral Interpretation

Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection

Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition

Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening

High Resolution Mass Spectrometry and Drug Metabolite Identification

Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging

Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies

Quantitative Drug Metabolism with Accelerator Mass Spectrometry

Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions

Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS

Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices

Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress

LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786613052322

9780470934692

0470934697

9781283052320

1283052326

9780470929261

047092926X

9780470929278

0470929278

OCLC:

716211010