Metabolic syndrome : from risk factors to management / Michael J. Blaha, Rajesh Tota-Maharaj.

Format:

Book

Author/Creator:

Blaha, Michael J.

Contributor:

Tota-Maharaj, Rajesh.

Language:

English

Subjects (All):

Metabolic syndrome.

Diabetes.

Physical Description:

1 online resource (222 p.)

Edition:

1st ed.

Place of Publication:

Torino : SEEd, c2012.

Language Note:

English

Summary:

Increased caloric intake, increased refined carbohydrate consumption, and physical inactivity have led to an explosion in the worldwide incidence of abdominal obesity and the emerging epidemic of insulin resistance, resulting in an increase of metabolic syndrome. Physicians can use the metabolic syndrome concept to guide focused lifestyle changes, lower blood pressure goals, and earlier intervention with aspirin, LDL-lowering drugs, and perhaps insulin-sensitizing medications. The comprehensive "ABCDE" approach presented in this book provides a memory tool for use in everyday clinical practice

Contents:

Intro

Title page

Colophon

Table of Contents

Introduction

The Metabolic Syndrome. A Global Problem

A Global Problem

What is the Metabolic Syndrome?

Why is the Metabolic Syndrome Concept Useful?

Misunderstandings about Use of Metabolic Syndrome

Why is the Metabolic Syndrome so Interesting?

References

Defining the Metabolic Syndrome

Early History of the Metabolic Syndrome

Pathophysiology vs. Predictive Value

Criticisms of the Metabolic Syndrome

The "Harmonized" Definition of Metabolic Syndrome

Causes and Components of the Metabolic Syndrome

Genetics of the Metabolic Syndrome

Abdominal Obesity

Insulin Resistance

Atherogenic Dyslipidemia

Essential Hypertension

Glucose Intolerance

Subclinical Inflammation

Fatty Liver Disease

Obstructive Sleep Apnea

Consequences of the Metabolic Syndrome

Cardiovascular Disease

Type 2 Diabetes

Microalbuminuria and Chronic Kidney Disease

Sexual Dysfunction (Men and Women)

Cognitive Decline

Cancer

The Comprehensive "ABCDE" Approach to Management

Rationale for a Comprehensive Approach

The ABCDE approach

Assessment of Cardiovascular Risk

Traditional Risk Models

Lifetime Risk

Metabolic Syndrome and Unaccounted Risk

Emerging Cardiometabolic Risk Factors

Reclassification with the Metabolic Syndrome

Novel Risk Detection Strategies

Aspirin and Antithrombotics

Mechanisms of Increased Thrombosis in the Metabolic Syndrome

Brief Overview of Platelet Function

Therapies With Available Evidence

Possible Aspirin Resistance in the Metabolic Syndrome

Other Therapies

Treatment recommendations

Blood Pressure

Hypertension

Definition.

Mechanisms of Increased Blood Pressure in the Metabolic Syndrome

Lifestyle Therapy

Pharmacologic Agents: The Renin‑Angiotensin-Aldosterone Axis

Thiazide Diuretics

Beta-Blockers

Calcium Channel Blockers

Metabolic Considerations. Progression to Diabetes

Blood Pressure Target

Guidelines and Recommendations

Cholesterol

Mechanisms of Atherogenic Dyslipidemia

Measurement

Therapies with Available Evidence

Diet and Weight Management

Weight Loss

The Mediterranean Diet

The Low Glycemic Index Approach

Sugar Sweetened Beverages

The Benefit of Nuts

Pharmacologic and Surgical Therapy for Obesity

Refer to a Nutritionist?

Diabetes Prevention

Progression to Type 2 Diabetes

Clinical Trial Evidence

Gaps in the Evidence

Guidelines

Exercise Therapy

Fitness

Mechanisms of Harm from Sedentary Lifestyle: Decreased Fitness

Mechanisms of Harm from Sedentary Lifestyle: Increased Fatness

Exercise: A Selective Therapy for Metabolic Syndrome?

Guideline Recommendations

Metabolic Syndrome in the Pediatric Population

The Unique Challenge of Pediatric Metabolic Syndrome

Defining Pediatric Metabolic Syndrome

Scientific Statement from the American Heart Association

Population-Based Treatment Strategies Targeted at Youth

Summary of Treatment Approaches

Appendix. Clinical trials

Finnish Diabetes Prevention Study

Diabetes Prevention Program (DPP)

JPAD Trial

POPADAD Trial

ACCORD Blood Pressure Trial

JUPITER trial

VA-HIT trial

ACCORD Lipid trial

AIM-HIGH trial

JELIS trial

Lyon Heart Study

Esposito Mediterranean Diet Trial

DREAM Trial

ACT-NOW Trial

CANOE trial

Tjønna Exercise Trial.

CPAP for the Metabolic Syndrome

Authors.

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

88-97419-20-8

OCLC:

802055207