Enzyme defects and immune dysfunction.

Format:

Book

Conference/Event

Conference Name:

Symposium on Enzyme Defects and Immune Dysfunction (1978 : London, England)

Series:

Ciba Foundation symposium. New series ; 68.

Ciba Foundation symposium. New series ; 68

Language:

English

Subjects (All):

Immunological deficiency syndromes--Congresses.

Immunological deficiency syndromes.

Adenosine deaminase--Congresses.

Adenosine deaminase.

Purines--Metabolism--Congresses.

Purines.

Enzymes--Congresses.

Enzymes.

Physical Description:

1 online resource (301 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Amsterdam ; New York : Excerpta Medica, 1979.

Language Note:

English

Summary:

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Contents:

Enzyme Defects and Immune Dysfunction; Contents; Chairman's introduction; Adenosine deaminase and purine nucleoside phosphorylase deficiency: how they were discovered and what they may mean; Discussion; Buridan's ass: one man's view of the immune system; Discussion; Clinical delineation of adenosine deaminase deficiency; Discussion; Immunological aberrations in purine nucleoside phosphorylase deficiencies; Discussion; Immunodeficiency due to transcobalamin II deficiency; Discussion; General Discussion I Model systems for study of enzyme deficiencies

Nucleotide metabolism in cultured T cells and in cells of patients deficient in adenosine deaminase and purine nucleoside phosphorylase Discussion; Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents; Discussion; Ecto 5'-nucleotidase deficiency in primary hypogammaglobulinaemia; Discussion; General Discussion II The methylation hypothesis of adenosine toxicity; Enzymology of immunodeficiency states; Allosteric regulation of calf thymus ribonucleotide reductase; Discussion

Adenosine deaminase: characteristics of the normal and mutant forms of the human enzyme Discussion; Purine nucleoside phosphorylase: the normal enzyme and structural alterations in immunodeficiency disease; Discussion; Purine nucleoside phosphorylase : immunodetection and characterization of the human enzyme; Enzyme replacement and other biochemical approaches to the therapy of adenosine deaminase deficiency; Discussion; An approach to the restoration of T cell function in a purine nucleoside phosphorylase deficient patient; Discussion; Purine metabolism in adenosine deaminase deficiency

Final General Discussion Selective treatment of lymphoid malignancy with adenosine deaminase inhibitors Defects in differentiation underlying ADA and PNP deficiency; Search for new enzyme deficiencies; Index of contributors; Subject index

Notes:

"Symposium on Enzyme Defects and Immune Dysfunction, held at the Ciba Foundation, London, 7th-9th November 1978"--Participants page.

Includes bibliographical references and indexes.

ISBN:

9786613694188

9781280783791

1280783796

9780470720516

0470720514

9780470718193

0470718196

OCLC:

797918439