The neutrophils : new outlook for old cells / editor, Dmitry Gabrilovich, H. Lee Moffitt Cancer Center, USA, University of South Florida, USA.

Format:

Book

Contributor:

Gabrilovich, Dmitry I., editor.

Series:

Gale eBooks

Standardized Title:

Neutrophils (2013)

Language:

English

Subjects (All):

Neutrophils.

Physical Description:

1 online resource (xxiii, 422 pages) : illustrations (some color)

Edition:

3rd ed.

Place of Publication:

London : Imperial College Press, [2013]

Language Note:

English

Summary:

This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of

Contents:

List of Contributors; Preface; Contents; Chapter 1: Molecular Regulation of Granulopoiesis Sachin Kumar and Marie-Dominique Filippi; 1.1 Introduction; 1.2 Sequential Steps of PMN Development; 1.2.1 From HSC to granulocytic precursors; 1.2.2 Final stages of granulocytic maturation - Acquisition of granulocyte characteristics; 1.3 Regulation of Steady State Granulopoiesis; 1.3.1 Growth factors; 1.3.1.1 G-CSF: Sources and functions; 1.3.1.2 G-CSFR and downstream signaling pathways; 1.3.1.3 G-CSFR signaling: Instructive or permissive?; 1.3.2 Transcription factors (TF)

1.3.2.1 PU.1 - Generation of CMP from HSC1.3.2.2 C/EBPα - Generation of GMP from CMP; 1.3.2.3 C/EBPε - Terminal stages of differentiation; 1.3.2.4 Gfi-1 - Terminal stages of differentiation; 1.3.2.5 Other transcription factors important for granulopoiesis; 1.3.2.5.1 Retinoic acid receptors; 1.3.2.5.2 HoxA10; 1.3.2.5.3 LEF-1; 1.3.3 MicroRNA; 1.3.4 Cell cycle regulation; 1.4 Emergency Granulopoiesis; 1.5 Conclusion; References; Chapter 2: The Neutrophil Respiratory Burst Oxidase Mark T. Quinn; 2.1 Introduction; 2.2 NADPH Oxidase Components; 2.2.1 Flavocytochrome b; 2.2.2 p47phox; 2.2.3 p67phox

2.2.4 p40phox2.2.5 Rac; 2.2.6 Rap1A; 2.3 Oxidase Protein Binding Interactions; 2.3.1 Flavocytochrome b-p47phox interactions; 2.3.2 p40phox-p47phox-p67phox interactions; 2.3.3 Rac interactions; 2.4 Model of NADPH Oxidase Assembly; 2.5 Oxidant Production; 2.5.1 Superoxide anion (O2 -); 2.5.2 Hydrogen peroxide (H2O2); 2.5.3 Hypochlorous acid (HOCl); 2.5.4 Hydroxyl radical (HO); 2.5.5 Singlet oxygen ( 1O2 *); 2.5.6 Nitric oxide (NO) and peroxynitrite (ONOO-); 2.7 Summary; Acknowledgments; References

Chapter 3: Novel Neutrophil Receptors and Their Signal Transduction Nicole R. Fortenbery, Xianhong Chen and Sheng Wei3.1 Introduction; 3.2 Siglecs; 3.2.1 Identification of siglecs; 3.2.2 Characterization of siglecs; 3.2.3 Siglec-5; 3.2.4 Siglec-9; 3.2.5 Siglec-14; 3.2.6 Siglec signaling; 3.2.7 Clinical applications; 3.3 Triggering Receptor Expressed by Myeloid Cells (TREM); 3.3.1 Identification of TREM; 3.3.2 Characterization of TREM-1; 3.3.3 TREM-1-DAP12 and signal transduction; 3.3.4 TREM-1 ligand(s); References

Chapter 4 Mechanisms of Neutrophil Migration Fong W. Lam, Rolando E. Rumbaut and Alan R. Burns4.1 Introduction; 4.2 Historical Perspective on Leukocyte Adhesion and Emigration (1669-1955); 4.2.1 The first observations; 4.2.2 Mechanistic insight; 4.3 Molecular Adhesive Events Preceding Neutrophil Transendothelial Migration; 4.4 Integrin Regulation of Neutrophil Transendothelial Migration; 4.5 Paracellular Neutrophil Transendothelial Migration; 4.5.1 Endothelial cleft organization; 4.5.2 Tight junctions and preferred transmigration sites; 4.5.3 Adherens junctions; 4.5.4 Gap junctions

4.5.5 PECAM-1

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

ISBN:

9781299462922

1299462928

9781848168374

1848168373

OCLC:

841461183