Insulin resistance : new developments / John Freeman and Scott Newman, editors.

Format:

Book

Contributor:

Freeman, John.

Newman, Scott.

Series:

Endocrinology research and clinical developments.

Novinka.

Endocrinology research and clinical developments

Novinka

Language:

English

Subjects (All):

Insulin resistance.

Physical Description:

1 online resource (125 p.)

Edition:

1st ed.

Place of Publication:

Hauppauge, N.Y. : Nova Science Publishers, Inc., 2013.

Language Note:

English

Summary:

The hallmark of insulin resistance is an obstacle to glucose uptake, resulting in hyperglycemia and hyperinsulinemia as well as type 2 diabetes mellitus. The prevalence of diabetes mellitus is rapidly increasing worldwide and is becoming an important health problem. In this book, the authors present current research in the study of insulin resistance including: the pathophysiological basis for antioxidant therapy of insulin resistance; new insight into the regulation of insulin resistance; burn injury and its association with insulin resistance and hyperglycemia which complicates clinical management; and lipoprotein lipase and its role in insulin resistance.

Contents:

Intro

INSULIN RESISTANCE

CONTENTS

PREFACE

PATHOPHYSIOLOGICAL BASISFOR ANTIOXIDANT THERAPY OF INSULIN RESISTANCE

ABSTRACT

INTRODUCTION

PATHOPHYSIOLOGY OF INSULIN RESISTANCE

Insulin-Resistance: Mechanisms of Disease

Glucose Toxicity in IR

IR and Oxidative Stress Cross-Talking

Polyol Pathway

Glucosamine Pathway

Kinase C Protein Activation

TNF-alpha Activate JNK

Advanced Glycation End Products and Oxidative Stress (AGEs)

ANTIOXIDANT THERAPY IN INSULIN-RESISTANCE

Resveratrol

Antioxidant Effect of Resveratrol in Hepatoprotection

Antioxidant Effect of Resveratrol in Pancreatic Protection

Anti-Obesity Effects

Anti-Diabetic Effects

Antioxidant Vitamins

Flavonoids

Other Antioxidants

CONCLUSION AND PERSPECTIVES

REFERENCES

NEW INSIGHT INTO THE REGULATION OF INSULIN RESISTANCE

1. INTRODUCTION

2. THE EFFECT OF ENDOCRINE HORMONES ON INSULIN RESISTANCE

2.1. Galanin and Insulin Resistance

2.2. Ghrelin and Insulin Resistance

2. 3. Leptin and Insulin Resistance

2.4. Adiponectin and Insulin Resistance

2.5. RBP4 and Insulin Resistance

3. THE ROLE OF THE AUTONOMIC NERVOUS SYSTEM IN REGULATING INSULIN RESISTANCE

4. THE GASTROINTESTINAL TRACT MICROBIOTA IN THE DEVELOPMENT OF INSULIN RESISTANCE

5. PPARS AND INSULIN RESISTANCE

6. VITAMIN D DEFICIENCY IN THE DEVELOPMENT OF INSULIN RESISTANCE

7. CURRENT GUIDELINES ON RISK FACTORS FOR INSULIN RESISTANCE, DIRECT AND INDIRECT INSULIN RESISTANCE ASSESSMENT METHODS

7.1. CRP

7.2. Hyperinsulinemic Euglycemic Glucose Clamp

7.3. Oral Glucose Tolerance Test

7. 4. HOMA- Insulin Resistance (IR)

8. THE NEW INSIGHT INTO PRIMARY PREVENTION AND THERAPY OF INSULIN RESISTANCE

8.1. SGLT2

8.2. MicroRNAs

CONCLUSION

REFERENCES.

INSULIN RESISTANCE AFTER SEVERE BURN INJURY

ABBREVIATIONS

MATERIALS AND METHODS

RESULTS

Blood Glucose Levels before and after EIC

PET Study of Glucose Uptake, Oxygen Extraction Fraction and Blood Flow in Hind Limb Skeletal Muscle

Changes in Endogenous Glucose Production After EIC

DISCUSSION

ACKNOWLEDGMENTS

LIPOPROTEIN LIPASE AND INSULIN RESISTANCE

BACKGROUND OF LIPOPROTEIN LIPASE (LPL)

RELATIONSHIP BETWEEN LPL AND LIPID METABOLISM AND ATHEROSCLEROSIS

EFFECT OF LPL ACTIVATOR NO-1886 ON LPL, LIPID METABOLISM AND ATHEROSCLEROSIS

EFFECT OF LPL ACTIVATOR NO-1886 ON FATTY LIVER

RELATIONSHIP BETWEEN LPL AND OBESITY AND INSULIN RESISTANCE

INDEX.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record and cip data provided by publisher.

ISBN:

1-62417-408-6

OCLC:

923665593