Silica nanoparticles : preparation, properties and uses / Juan Vivero-Escoto, editor.

Format:

Book

Contributor:

Vivero-Escoto, Juan.

Series:

Nanotechnology science and technology series.

Chemical engineering methods and technology.

Nanaotechnology science and technology

Chemical engineering methods and technology

Language:

English

Subjects (All):

Nanosilicon.

Nanoparticles.

Biotechnology--Materials.

Biotechnology.

Silica dust--Industrial applications.

Silica dust.

Physical Description:

1 online resource (302 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2012.

Language Note:

English

Summary:

In this book, the authors present topical research in the study of the preparation, properties and use of silica nanoparticles. Topics discussed include the reactivity of inorganic radicals and excited triplet states in colloidal silica suspensions; multifunctional mesoporous silica nanoparticles for controlled drug delivery, multimodal imaging and simultaneous imaging and drug delivery; monodisperse luminescent silica nanoparticles and their application to DNA microarray technology.

Contents:

Intro

SILICA NANOPARTICLES PREPARATION, PROPERTIES AND USES

Library of Congress Cataloging-in-Publication Data

CONTENTS

PREFACE

Chapter 1 SILICA NANOPARTICLE AS CARRIER FOR BIOSENSING

ABSTRACT

1. INTRODUCTION

2. SYNTHESIS OF SILICA-BASED NPS

3. DOPED SILICA NPS

3.1. Luminophore-Doped Silica NPs

3.2. Quantum Dots-Doped Silica NPs

3.3. Magnetic Particles-Doped Silica NPs

3.4. Noble Metal Particles-Doped Silica NPs

3.5. Bifunctional Silica-Based NPs

4. CONJUGATION OF SILICA-BASED NPS WITH DESIRED BIOMOLECULES

4.1. Physisorption of Biomolecules

4.2. Entrapment of Biomolecules by the Sol-Gel Method

4.3. Affinity-Based Interactions

4.4. Covalent Binding

5. SILICA-BASED NPS AS CARRIERS FOR BIOSENSING

5.1. Targeting of Cells

5.2. Ultrasensitive DNA Detection

5.3. Biosenors

5.4. Immunoassay

CONCLUSION

REFERENCES

Chapter 2 REACTIVITY OF INORGANIC RADICALS AND EXCITED TRIPLET STATES IN COLLOIDAL SILICA SUSPENSIONS

2. QUENCHING OF BENZOPHENONE TRIPLET STATES BY MODIFIED SILICA NANOPARTICLES

2.1. Time- Resolved Phosphorescence Experiments

2.2. Laser Flash-Photolysis (LFP) Experiments

2.2.1. LFP with BP Solutions

2.2.2. LFP with NP1 and NP2 Suspensions in BP Solutions

3. REACTION MECHANISMS OF INORGANIC RADICALS AT THE SILICA/WATER INTERFACE

3.1. Generation of Grafted Radicals

3.2. SO4-

3.2.1. NPS Formation and Reactivity

3.2.2. SiO Formation and Reactivity

3.2. Cl / Cl2-

3.3. HPO4-

3.4. (SCN)2-

Chapter 3 MULTIFUNCTIONAL MESOPOROUS SILICA NANOPARTICLES FOR CONTROLLED DRUG DELIVERY, MULTIMODAL IMAGING AND SIMULTANEOUS IMAGING AND DRUG DELIVERY

DEDICATION

1. INTRODUCTION.

2. MSN-BASED CONTROLLED DRUG DELIVERY SYSTEMS

2.1. MSN-Based Stimuli-Responsive Drug Delivery Systems

2.2. MSN-Based Internal Stimuli-Responsive Drug Delivery Systems

2.2.1. pH

2.2.2. Redox Potential

2.2.3. Biomolecules

2.3. External Stimuli-Responsive Drug Release

2.3.1 Radiation

2.3.2. Oscillating Magnetic Field

3. MSN-BASED IMAGING PROBES

3.1. MSN-Based Optical Imaging Agents

3.2. MSN-Based MR Imaging Agents

4. BIOCOMPATIBILITY, PHARMACOKINETICS AND BIODISTRIBUTION OF MESOPOROUS SILICANANOPARTICLES

5. IN VIVO SIMULTANEOUS IMAGING AND DRUG DELIVERY

ACKNOWLEDGMENTS

REVIEWED BY

Chapter 4 MESOPOROUS SILICA NANOPARTICLES AS A DRUG DELIVERY SYSTEM

2. SILICA PREPARATION METHODS

2.1. Conventional Preparation Method

2.2. Fluorescent Silica Nanoparticles

2.3. Functionalised Silica Nanoparticles

3. INFLUENCE OF STRUCTURAL CHARACTERISTICS

3.1. Pore Size

3.2. Surface Area

3.3. Pore Volume

4. SILICA NANOPARTICLES AS A DRUG DELIVERY SYSTEM

4.1. Controlled Drug Delivery

4.2. MSNs in Cancer Treatment

4.3. MSNs as Biosensors

4.4. Gatekeeping

5. BIOCOMPATIBILITY OF SILICA NANOPARTICLES

5.2. Cellular Uptake

5.3. Cytotoxicity

Chapter 5 SILICA-BASED HYBRID NANOMATERIALS WITH WELL-DEFINED ARCHITECTURES

2. FABRICATION OF SILICA NANOSTRUCTURES

2.1. Solid Silica Nanostructures

2.2. Hollow Silica Nanostructures

2.3. Nanoporous Silica Nanostructures

2.4. Other Silica Nanostructures

3. SILICA/POLYMER HYBRID NANOSTRUCTURES

3.1. Polymer Grafting from Silica Surfaces

3.2. Silica Deposited onto Polymer Self-Assembled Architectures

4. SILICA/METAL NANOPARTICLES HYBRID NANOSTRUCTURES

4.1. Surfaces Immobilized Metal Nanoparticles.

4.2. Matrix Entrapped Metal Nanoparticles

4.2.1. Route I to Silica/Metal Nanostructures

4.2.2. Route II to Silica/Metal Nanostructures

4.3. Rattle-Like Silica/Metal Nanoparticle Hybrids

5. SILICA/CARBON NANOSTRUCTURES

5.1. Silica/CNT Hybrid Nanostructures

5.1.1. Covalent Processes

5.1.2. Non-Covalent Processes

5.2. Silica/Graphene Sheets Nanostructures

5.3. Other Silica/Carbon Nanomaterials

6. SILICA-BASED JANUS NANOSTRUCTURES

7. CHALLENGES AND OUTLOOK

Chapter 6 FUNCTIONAL SILICA NANOPARTICLES SYNTHESIZED BY WATER-IN-OIL MICROEMULSION

1.1. Interest of Functional Nanoparticles and Interest of Silica as Matrix

1.2. Possibilities for the Synthesis of Silica Nanoparticles

1.3. Synthesis of Silica Nanoparticles by Water-in-Oil Microemulsion

1.4. Different Synthesis Strategies

1.5. Different Nanoparticle Microstructures

1.6. A Wide Range of Already-Published Materials

1.7. Complementary of Microemulsions to Other Techniques

1.8. Surface Functionalization in Microemulsions

1.9. Our Materials and Chapter Topic

2. SYNTHESIS OF THE FUNCTIONAL SILICA NANOPARTICLES

2.1. Water-in-Oil Microemulsions

2.2. Silica Synthesis in Water-in-Oil Microemulsions

2.3. Washing and Collection of the Silica Nanoparticles

2.4. Experimental Part

3. CHARACTERIZATIONS AND POTENTIAL APPLICATIONS OF THE FUNCTIONAL SILICA NANOPARTICLES

3.1. SiO2 Nanoparticles for Scratch Resistant Glass

3.2. CeO2@SiO2 Anti-UV Nanoparticles

3.3. ZnFe2O4@SiO2 and γ-Fe2O3@SiO2 Magnetic Nanoparticles

3.4. Cluster@SiO2 Luminescent Nanoparticles

3.5. γ-Fe2O3-Cs2[Mo6Br14]@SiO2 Bi-Functional Nanoparticles

Chapter 7 BIOMEDICAL APPLICATIONS OF NANOSILICA

INTRODUCTION.

SILICA NANOPARTICLES

Preparation and Properties of Silica Nanoparticles

Modification by Chemical Interaction

Modification by Physical Interaction

Applications

DRUG DELIVERY SYSTEMS

Polymers Used in Drug Delivery Systems

Application of Nanosilica in Drug Delivery

TISSUE ENGINEERING

Biomaterials and Tissue Engineering

Polymers Used in Tissue Engineering Scaffolds

Synthetic Polymers

Natural Polymers

Application of Nanosilica in Tissue Engineering

DENTISTRY

LIGHT-CURED DENTAL NANOCOMPOSITES

APPLICATION OF NANOSILICA IN DENTISTRY

Chapter 8 MONODISPERSE LUMINESCENT SILICA NANOPARTICLES: SYNTHESIS, CHARACTERIZATION AND APPLICATION TO THE DNA MICROARRAY TECHNOLOGY

2. SYNTHESIS, FUNCTIONALIZATION AND CHARACTERIZATION OF DYE DOPED SILICA NANOPARTICLES

2.1. Synthesis and Functionalization Procedure

2.2. Optimization of Dye Loading

2.3. Influence of APTES

2.4. Influence of NH3

2.5. Diluted Synthesis

3. APPLICATION OF DYE DOPED NANOPARTICLES TO DNA MICROARRAY TECHNOLOGY

3.1. Bioconjugation of Nanoparticles with Streptavidin

3.2. HPV Probe Oligonucleotide Design and Microarray Printing

3.3. PCR Amplification of the Sample DNA Strands and Hybridization

3.4. Application to the DNA Microarray Technology for HPV Detection

Chapter 9 DEGREE OF DISPERSION AND COAGULATION OF SILICA NANOPARTICLES DETERMINED BY USING AN ELECTRIC FIELD

INTRODUCTION

METHODOLOGY

RESULTS AND DISCUSSION

Effect of Supply Voltages

Mechanism Verification: Configuration of Pearl Chains under an Electric Field

Chapter 10 TEMPERATURE-RESPONSIVE DNA-CAPPED MESOPOROUS SILICA NANOPARTICLES BASED DELIVERY SYSTEM

RESULTS AND DISCUSSION

EXPERIMENTAL SECTION

Reagents and Materials

Characterization of Materials

Synthesis of PAP-MSNs

Loading of the [Ru(bipy)3]2+ Complex to PAP-MSNs

Capping of [Ru(bipy)3]2+-Loaded PAP-MSNs with ds-Oligonucleotides

Release of [Ru(bipy)3]2+ from Oligo-Capped [Ru(bipy)3]2+-Loaded PAP-MSNs

INDEX.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-62257-030-8

OCLC:

923665824