Nitrous oxide and neurotransmission / Mark A. Gillman.

Format:

Book

Author/Creator:

Gillman, Mark A.

Series:

Pain Management - Research and Technology

Language:

English

Subjects (All):

Nitrous oxide--Physiological effect.

Nitrous oxide.

Neurochemistry.

Neurotransmitters.

Physical Description:

1 online resource (309 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2012.

Language Note:

English

Summary:

As a lipid-soluble molecule, nitrous oxide enters the brain rapidly to alter the flow of information along a multitude of neuronal pathways and synapses by interfering with membrane ion channels and the action of key neurotransmitters. Some neurotransmitters, such as dopamine and the endogenous opioid peptides, act through G-protein coupled receptors mainly to adjust or modulate synaptic strength, whereas GABA and glutamate are amino acids known for their strong inhibitory or excitatory synaptic effects. Thus, nitrous oxide and nitric oxide belong to what now is becoming a sizable group of messenger molecules with signaling properties unlike any of the known non-gaseous chemical neurotransmitters. This book examines nitrous oxide and its effects on the various neurotransmitter systems and ion channels of the brain. This book also discusses how these effects could give rise to all the documented clinical actions of this relatively simple gas.

Contents:

Intro

NITROUS OXIDE AND NEUROTRANSMISSION

Library of Congress Cataloging-in-Publication Data

CONTENTS

FOREWORD

PREFACE

Chapter 1: NITROUS OXIDE AND THE ENDOGENOUS OPIOID SYSTEM

THE ENDOGENOUS OPIOID SYSTEM

DEMONSTRATION OF OPIOID RECEPTOR BLOCKADE THAT IS STEREOSPECIFIC

DEMONSTRATION OF CROSS-TOLERANCE AND DEPENDENCE ON OPIOIDS

RADIOACTIVE RECEPTOR-BINDING ASSAYS

ISOLATED ORGAN BATH EXPERIMENTS

IN VIVO BRAIN IMAGING STUDIES

HOW NITROUS OXIDE INTERACTS WITH OPIOID RECEPTORS ON A PHYSICO-CHEMICAL BASIS: AN HYPOTHESIS

REFERENCES

Chapter 2: NITROUS OXIDE AND THE DOPAMINE SYSTEM

DOPAMINE RECEPTORS

PHARMACOLOGICAL STUDIES

SYNTHESIS

Chapter 3: NITROUS OXIDE AND THE ADRENERGIC SYSTEM

ADRENERGIC RECEPTORS

EVIDENCE THAT NITROUS OXIDE HAS ADRENERGIC ACTIONS

INVOLVEMENT OF ΑLPHA-ADRENERGIC RECEPTORS

Chapter 4: NITROUS OXIDE AND THE CYS-LOOP SUPERFAMILY SYSTEMS (GABA, NICOTINIC ACETYLCHOLINE GLYCINE AND SEROTONIN3)

CYS-LOOP RECEPTORS

GABA RECEPTORS

NICOTINIC ACETYLCHOLINE RECEPTORS

GLYCINE RECEPTORS

SEROTONIN3 RECEPTORS

Chapter 5: NITROUS OXIDE AND THE GLUTAMINERGIC SYSTEM

GLUTAMATE RECEPTORS

INTERACTION OF NITROUS OXIDE WITH GLUTAMATE RECEPTORS: CLUES FROM THE USE OF NITROUS OXIDE FOR AMELIORATING SUBSTANCE ABUSE

INTERACTION OF NITROUS OXIDE WITH GLUTAMATE RECEPTORS: CLUES FROM THE NEUROPROTECTIVE ACTIONS OF NITROUS OXIDE

EVIDENCE THAT NITROUS OXIDE INTERACTS WITH GLUTAMINERGIC RECEPTORS

Chapter 6: NITROUS OXIDE AND VOLTAGE-GATED ION CHANNELS

EFFECT OF NITROUS OXIDE ON POTASSIUM CHANNELS

EFFECT OF NITROUS OXIDE ON CALCIUM CHANNELS

EFFECT OF NITROUS OXIDE ON SODIUM/CALCIUM EXCHANGE

REFERENCES.

Chapter 7: NITROUS OXIDE, NITRIC OXIDE AND NEUROTRANSMISSION

NITRIC OXIDE AND NITROUS OXIDE

Chapter 8: CLINICAL APPLICATIONS I-ANALGESIA, ANXIOLYSIS, ANTISTRESS AND ANAESTHESIA

HISTORICAL PERSPECTIVE

ANALGESIA

ANXIOLYTIC ACTION OF NITROUS OXIDE

ANTISTRESS

ANAESTHESIA

Chapter 9: CLINICAL APPLICATIONS II- TREATMENT OF SUBSTANCE ABUSE

INTRODUCTION - DISTINGUISHING BETWEEN PSYCHOTROPIC ANALGESIC NITROUS OXIDE AND ANAESTHETIC NITROUS OXIDE

WHY PAN AND NOT ANAESTHETIC NITROUS OXIDE?

HOW PAN AMELIORATES SUBSTANCE ABUSE WITHDRAWAL STATES

PAN FOR TREATING WITHDRAWAL STATES

PAN FOR TREATING OTHER SUBSTANCES OF ABUSE APART FROM ALCOHOL

RECEPTOR HYPOTHESIS OF THE ALCOHOL WITHDRAWAL STATE

CURRENT STATUS OF PAN FOR SUBSTANCE ABUSE WITHDRAWAL

CONCLUSION

INDEX.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61470-138-5

OCLC:

923668957