DNA replication and mutation / Raymond P. Leitner, editor.

Format:

Book

Contributor:

Leitner, Raymond P.

Series:

DNA and RNA : Properties and Modifications, Functions and Interactions, Recombination and Applications

DNA and RNA

Language:

English

Subjects (All):

DNA replication.

DNA--Synthesis.

DNA.

Physical Description:

1 online resource (204 p.)

Edition:

1st ed.

Place of Publication:

Hauppauge, NY : Nova Science, 2012.

Language Note:

English

Summary:

In this book, the authors present current research in the study of DNA replication and mutation, including connections between BLM and the Fanconi anemia pathway in the repair of replication fork damage; the mutagenic potential of methacrylates used in restorative dentistry; DNA mutation of the progranulin gene in familial frontotemporal lobar degeneration; effect of DNA polymerase a-inhibitor dehydroaltenusin on DNA replication in cultured cells; gel-based methods of DNA-binding zinc II complexes in the detection of DNA mutations and DNA mutations and genetic coding.

Contents:

""DNA REPLICATIONAND MUTATION""; ""DNA AND RNA: PROPERTIESAND MODIFICATIONS, FUNCTIONSAND INTERACTIONS, RECOMBINATIONAND APPLICATIONS""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Preface""; ""Connections between BLMand the Fanconi AnemiaPathway in the Repair ofReplication Fork Damage""; ""Abstract""; ""RecQ DNA Helicases""; ""BLM and Regulationof Homologous Replication""; ""Connections between FANCM of the FanconiAnemia Pathway and BLM""; ""Connections between FANCJ of the FAPathway and BLM""

""The Structure-Specific EndonucleaseSLX4-SLX1 and Its Relationshipto BLM and the FA Pathway""""Conclusion""; ""Acknowledgments""; ""References""; ""Mutagenic Potentialof Methacrylates Usedin Restorative Dentistry""; ""Abstract""; ""Introduction""; ""Materials and Methods""; ""Chemicals""; ""Cells""; ""Cell Treatment""; ""Cell Viability""; ""Plasmid Relaxation Assay""; ""Comet Assay""; ""Oxidative Damage to DNA""; ""DNA Double-Strand Breaks Assays""; ""Apoptosis""; ""Cell Cycle""; ""Data Analysis""; ""Results""; ""Cell Viability""; ""DNA Damage In Vitro""

""DNA Damage in Human Gingival Fibroblasts""""DNA Double-Strand Breaks""; ""DNA Repair""; ""Oxidative Modifications to the DNA Bases""; ""Apoptosis""; ""Cell Cycle""; ""Discussion""; ""Acknowledgments""; ""Conflict of Interest Statement""; ""References""; ""DNA Mutation of theProgranulin (GRN) Gene inFamilial Frontotemporal LobarDegeneration (FTLD): A Studyof the Pathology of Nine Cases""; ""Abstract""; ""Introduction""; ""Heterogeneity of FTLD-TDP""; ""DNA Mutations""; ""Objectives""; ""Materials and Methods""; ""Cases""; ""Histological Methods""; ""Morphometric Measurements""

""Measurement of Density of Inclusions""""Spatial Patterns of the Inclusions""; ""Laminar Distribution""; ""Density of TDP-43Immunoreactive Inclusions""; ""Spatial Patterns of TDP-43Immunoreactive Inclusions""; ""Laminar Distribution of TDP-43Immunoreactive Inclusions""; ""Conclusion""; ""Acknowledgments""; ""References""; ""Effect of a Specific MammalianDNA Polymerase α-Inhibitor,Dehydroaltenusin, on DNAReplication in Cultured Cells""; ""Abstract""; ""Abbreviations""; ""1. Introduction""; ""2. Production and Isolationof Dehydroaltenusin""

""3. Effect of Dehydroaltenusin on Polsand other DNA Metabolic Enzymes""""4. Mode of Pol α Inhibitionby Dehydroaltenusin""; ""5. Effect of Dehydroaltenusinon Human Cancer Cell Growth""; ""6. Inhibitory Properties of ehydroaltenusinon Human Cancer Cell Growth""; ""7. Effect of Dehydroaltenusin on DNAReplication in NIH3T3 Cells""; ""8. Discussion""; ""Conclusion""; ""Acknowledgments""; ""References""; ""Gel-Based Methods Using DNABindingZinc(II) Complexesfor the Detectionof DNA Mutations""; ""Abstract""; ""Introduction""; ""Zinc(II)�Cyclen""

""Zinc(II)�Cyclen PolyacrylamideGel Electrophoresis""

Notes:

Description based upon print version of record.

Includes bibliographical references (p. 158-177) and index.

Description based on print version record.

ISBN:

1-61942-455-X

OCLC:

923652879