Estrogen prevention for breast cancer / Zsuzsanna Suba, editor.

Format:

Book

Contributor:

Suba, Zsuzsanna.

Series:

Cancer etiology, diagnosis, and treatments.

Cancer etiology, diagnosis and treatments

Language:

English

Subjects (All):

Cancer--Hormone therapy.

Cancer.

Estrogen.

Breast--Cancer.

Breast.

Physical Description:

1 online resource (170 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, 2013.

Language Note:

English

Summary:

From the early 80s of the past century, clinical and epidemiological studies have increasingly pointed to an elevated breast, endometrial and ovarian cancer risk from high circulating estrogen levels. Estrogen deficiency as a cancer risk factor emerged first in 2007 in a study on Hungarian oral cancer cases based on the gender and age- related differences in tumor prevalence. Critical reevaluation of the contradictory results of hormone replacement therapy yielded a complete conversion that estrogen deficiency may confer cancer initiation. This book examines the deleterious interactions between estrogen deficiency and further hormonal disorders which illuminate the apparently controversial associations of obesity, light exposure and alcohol intake with breast cancer risk.

Contents:

Intro

ESTROGEN PREVENTION FOR BREAST CANCER

Library of Congress Cataloging-in-Publication Data

Contents

Preface

Acknowledgements

Chapter I: Discovery of Estrogen Deficiency as Common Cancer Risk Factor for Highly and Moderately Estrogen Dependent Organs

Abstract

Introduction

Risk Factors for Cancers of Highly Hormone Related Organs

Controversial Associations of Hormone Replacement Therapy and Cancer Risk

Shortcomings of Studies on the Correlations between HRT Use and Cancer Risk

Estrogen Deficiency and Cancer Risk in Postmenopausal Women

Moderate Estrogen Deficiency and Cancer Risk in Premenopausal Women

Conspicuous Differences between Cancer Epidemiology of Highly and Moderately Estrogen Dependent Organs

Extraovarian Estrogen Synthesis

Estrogen Deficiency in Men

Conclusion

References

Chapter II: Interaction between Insulin and Estrogen in the Regulation of Cell Proliferation and Carcinogenesis

Correlations between Insulin Resistance and Cancer Risk

Historical Review of Associations between Estrogen and Cancer Development

Molecular Mechanism of Interplay between the Actions of Estrogen and Insulin

Clinical Correlations between Estrogen Deficiency, Insulin Resistance and Cancer Risk

Chapter III: Dose Dependent Biphasic Effect of Alcohol on Estrogen Level and Cancer Risk

Ambiguous Biphasic Metabolic and Hormonal Effects of Moderate and Excessive Alcohol Consumption

Associations of Alcohol Consumption, Estrogen Level and Breast Cancer Risk

Alcohol Consumption, Hormonal Changes and Risk for Oral Cancer

Chapter IV: Estrogen Level May Be Protective for Breast Cancer in Obese Women

Introduction.

Grade and Distribution of Fat Deposition and Breast Cancer Risk

Age-Related Role of Obesity in the Prediction of Breast Cancer Risk

Effects of Reproductive Data and Menstrual Factors on Obesity-Associated Breast Cancer Risk

Effects of Exogenous Hormone Treatment on Breast Cancer Risk

Obesity Related Metabolic and Hormonal Disorders as Mediators of Breast Cancer Risk

Counteraction between Obesity Associated Insulin Resistance and Protective Circulatory Estrogen Level

Chapter V: Newly Recognized Player in Breast Cancer Risk: Light Deficiency

Differences in Breast Cancer Incidence and Mortality between African-American and White American Women

Excessive Cancer Risk of African-Americans and Dark Skinned Immigrants in Northern Geographic Regions

Traditional Concept Concerning the Oncostatic Capacity of Melatonin Hormone

Correlations between Excessive Melatonin Level, Other Endocrine Functions and Cancer Risk

Correlations among Light Exposure, Melatonin Level and Breast Cancer Risk

Chapter VI: Estrogen Prevention of Breast Cancer: A Critical Review

Background: Randomized HRT WHI Trials

Critique of the WHI HRT Trial Reporting

Estrogen and the Rates of Invasive Breast Cancer

Estrogen Benefit in Human Breast Cancer - Clinical Stage IV Breast Cancer

Estrogen Benefit in Breast Cancer: Basic Research Data and Mechanism of Action

Estrogen in Prevention of Breast Cancer? The Final 2000 - 2012 Reports

Chapter VII: Failures and Controversies of the Antiestrogen Treatment of Breast Cancer

Molecular Mechanisms of Estrogen Action

Estrogen Receptors and Their Actions.

Interplay between Alpha and Beta Estrogen Receptor Isoforms in the Regulation of Cell Proliferation and of Apoptotic Cell Death

Cross Talk between Receptor Signals of Estrogen and Growth Factors

Estrogen Receptors and Human Cancers

Estrogen Synthesis in Tumors

Antiestrogen and Estrogen in Cancer Therapy

Chapter VIII: Evolution of Estrogen Action in Breast Cancer: From Culprit to Killer

Evolution of Fashions in Breast Cancer Treatment and Prevention

Selective ER Modulation: Translation from the Laboratory to Clinical Practice

A Roadmap to Use SERMS to Prevent Multiple Diseases in Women

Raloxifene in Clinical Practice

Summary of SERMs

The Evolution of Acquired Resistance to Antihormonal Therapies

Molecular Mechanisms of the Apoptotic Action of Estrogens

Clinical Significance of Estrogen Induced Apoptosis

Acknowledgments

Index.

Notes:

"Nova biomedical."

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-62417-393-4

OCLC:

839699426