Osteoclasts : morphology, functions and clinical implications / Alexander J. Brown and Johanna S. Walker, editors.

Format:

Book

Contributor:

Brown, Alexander J.

Walker, Johanna S.

Series:

Cell biology research progress.

Human anatomy and physiology series.

Cell biology research progress

Human anatomy and physiology

Language:

English

Subjects (All):

Osteoclasts.

Physical Description:

1 online resource (182 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, Inc., 2012.

Language Note:

English

Summary:

In this book, the authors present current research in the study of the morphology, functions and clinical implications of osteoclasts. Topics include osteoclast formation and function and its risk in skeletal bone disease.

Contents:

Intro

OSTEOCLASTS

Contents

Preface

Modulation of Osteoclast Differentiation and Function in Rheumatoid Arthritis

Introduction

Osteoclasts in Rheumatoid Arthritis

Growth Factors

Macrophage Colony Stimulating Factor

Granulocyte Macrophage- Colony Stimulating Factor

Transforming Growth Factor-Beta

Tumor Necrosis Factor Super Family

Receptor Activator of NF-Kappa B Ligand

Tumor Necrosis Factor-Alpha

Osteoprotegerin

Interferon Family

Interleukin Family

Interleukin 1

Interleukin 6

Interleukin 10

Conclusion

Refrences

Osteoclast Formation and Function and Its role in Skeletal Bone Disease

Abstract

Multinucleation

Sealing Zone

Ruffled Border

Basolateral Membrane

OCs and Clinical Implications

Osteopetrosis

Pycnodysostosis

Paget's Disease

Osteoporosis

Cancer

Inflammatory Arthritis

Acknowledgments

References

The High Osteoclastogenic Potential of Human Osteosarcoma Cells: Reciprocal Interaction between MG63 Osteoblast-Like Cells and Osteoclast Precursors

1. Introduction

2. Cell Culture Models

2.1. MG63 Cell Line

2.2. Peripheral Blood Mononuclear Cells (PBMC)

3. Osteoclastogenic Potential of the MG63

Cell Line

3.1. Paracrine-Mediated Mechanisms

3.2. Cell-to-Cell Contact Mechanisms

4. Modulation of the MG63 Cell Behavior by Osteoclastic Cells

Osteoclast Biology in Paget's Disease of Bone

Osteoclast Phenotype in PDB

Viral and Genetic Factors in Paget's Disease of Bone

Role of p62 in Osteoclast Signaling

p62 as a Shuttling Factor

Role of p62 Mutations in Paget's Disease of Bone

Osteoclasts: The Major Actors in Bone Resorption

Introduction.

Osteoclast Differentiation and Activation

Osteoclasts and Immune System Talk

Osteoclasts in Bone Metastases

Osteoclasts in Periprosthetic Osteolysis

Osteoclasts in Pedriatic Disease

Osteoclasts in Osteoporosis

Role of the Immuno-Skeletal Interface in Physiological and Pathological Osteoclast Regulation

1. Physiological Osteoclast Formation and the Role of the RANK/RANKL/OPG Axis

2. Role of the Immuno-skeletal Interface in Physiological Osteoclast Renewal

a) T Cells and B Cells, the Centerpiece of Cell-mediated Immunity

b) T Cells and B Cells, Critical Regulators of Basal Osteoclastogenesis

c) Disruption of the Immuno-skeletal Interface and Bone Loss Associated with HIV-Infection

d) The immuno-skeletal Interface and Osteoclastic Bone Loss Associated with inflammatory Disease

e) Role of the Immuno-skeletal interface in Estrogen Deficiency-induced Bone Loss

Multiple Functions of Osteoclasts and Potential Usefulness of Phosphatidylserine-Containing Liposomes on Bone Diseases

Immune Fuctions of OCs

Angiogenic Functions of OCs

HSC Regulation Function of OCs

Effects of PSLs on OCs

Effects of PSLs on Macrophages/Miroglia

Effects of PSLs on DCs

Bone Formation and Osteoclastic Resorption after Implantation of beta-Tricalcium Phosphate (beta-TCP)

Materials and Methods

Experiment 1

Experiment 2

Results

Discussion

Osteoclasts of Patients with Neurofibromatosis 1 (NF1)

Short Communication

Index.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-62081-340-8

OCLC:

832756287