Microtubule Targets in Cancer Therapy [electronic resource].

Format:

Book

Author/Creator:

Fojo, Antonio Tito.

Series:

Cancer Drug Discovery and Development

Language:

English

Subjects (All):

Tumors.

Local Subjects:

Tumors.

Physical Description:

1 online resource (636 p.)

Edition:

1st ed.

Place of Publication:

Dordrecht : Springer, 2009.

Summary:

The family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This title presents an exploration of the dynamic potential of microtubules anti-cancer targets.

Contents:

An Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly; Molecular Mechanisms of Microtubule Acting Cancer Drugs; Microtubule Dynamics; Microtubule-Associated Proteins and Microtubule-Interacting Proteins; The Post-Translational Modifications of Tubulin; The Isotypes of Tubulin; The Tubulin Superfamily; Tubulin Proteomics in Cancer; Tubulin and Microtubule Structures; Destabilizing Agents; Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin; Antimicrotubule Agents That Bind Covalently to Tubulin

Microtubule Stabilizing AgentsMechanisms of Resistance to Drugs That Interfere with Microtubule Assembly; Resistance to Microtubule-Targeting Drugs; Microtubule Stabilizing Agents in Clinical Oncology; Investigational Anticancer Agents Targeting the Microtubule; Microtubule Damaging Agents and Apoptosis; Microtubule Targeting Agents and the Tumor Vasculature; Neurodegenerative Diseases; Structure, Function, and Regulation of the Microtubule Associated Protein Tau

Notes:

Description based upon print version of record.

OCLC:

437104720