Cell proliferation : processes, regulation and disorders / Changhong Zhang and Xiangqiong Zeng, editors.

Format:

Book

Contributor:

Zhang, Changhong, 1972-

Zeng, Xiangqiong, 1979-

Series:

Cell biology research progress series.

Cell biology research progress

Language:

English

Subjects (All):

Cell proliferation.

Cell differentiation.

Physical Description:

1 online resource (169 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Biomedical, 2013.

Language Note:

English

Summary:

This book is a compendium from national and international thought leaders in health care quality. The aim is to provide readers with diverse and leading views in the burgeoning field of quality, safety, and value. We do not intend to repeat or replace the seminal efforts of Avedis Donabedian and other pioneers in health care quality. Rather, the intent is to compliment the rich journey of continuous improvement in health care with a current, "state-of-the-art" view. The chapters in this book may be read in any order and asynchronously without compromising the value of the experience and education. Finally, we aim to stimulate further thought and action to help our patients and health care institutions in the quest to provide high-performance and high-reliability health care on top of a foundation of rapid, institutional learning.

Contents:

Intro

CELL PROLIFERATION: PROCESSES, REGULATION AND DISORDERS

Library of Congress Cataloging-in-Publication Data

Contents

Preface

Chapter I: Glutamate and its Receptors in Controlling Proliferation of Oligodendrocyte Progenitor Cells

Abstract

1. Introduction

2. OPCs Represent the Largest Pool of Proliferating Cells in the Brain

3. Glutamate Receptors on Oligodendroglial Progenitors and their Role during Cell Proliferation in Culture

4. Glutamatergic Synapses on Oligodendroglial Progenitors and their Possible Role during Proliferation

4.1. OPCs Receive Functional Synaptic Input from Neurons

4.2. Morphology of OPCs during Mitosis

4.3. Neuron-glial Synapses during Mitosis

4.4. Are Neuron-glia Synapses Involved in Regulation of OPC Proliferation?

5. Proliferation of Oligodendroglial Progenitors In Vivo and its Modulation by Electrical Activity in Axons

5.1. Neuronal Activity Controls Proliferation of Oligodendroglial Progenitors In Vivo

5.2. How do Electrically Active Axons Signal to Glial Cells to Divide?

Conclusion

Acknowledgments

References

Chapter II: The Two Faces of TGF-ß in Breast Cancer: Tumour Suppressor and Tumour Promoter

List of Abbreviations

1. Introduction of the TGF-ß Superfamily

2. The Mechanism of TGF-ß Signal Transduction

2.1. The TGF-β Pathway

2.2. Non-Smad Signalling

2.3. Regulation of the TGF-β-Induced Smad Pathway

3. The Dual Role of TGF-ß in Breast Cancer

3.1. Inhibition of Tumourigenesis

3.2. Promotion of Tumour Progression

3.3. EMT

3.4. From Primary Site to Circulation

3.5. Targeting Specific Organs

References.

Chapter III: MicroRNAs and Their Therapeutic Potential for Vascular Smooth Muscle Cell Proliferation in Restenosis

2. SMC Proliferation in Restenosis

3. MiRNAs in SMC Proliferation

3.1. miR-143 and miR-145

3.2. miR-221 and miR-222

3.3. miR-1 and miR-133

3.4. miR-21

3.5. miR-26a

3.6. miR-208a

3.7. let-7d

4. MiRNAs in Cell Cycle

Chapter IV: Impaired Proliferation as a Component of the Pathogenesis of Follicular Persistence Associated with Cystic Ovarian Disease

2. Regulation of the Cell Cycle in the Ovary

3. Ovarian Cysts

4. Altered Proliferation in Follicular Cysts

5. Decreased Apoptosis Contributes to Follicular Persistence

Chapter V: Extracellular Protein-Induced Plant Cell Proliferation

2. Cell Systems to Investigate Cell Proliferation

3. Conditioned Medium Enhances Cell Division during Somatic Embryogenesis

4. Chitinases/PR Proteins Involvement in Cell Proliferation

5. AGP-mediated Promotion of Cell Proliferation

6. Other Extracellular Proteins Identified during Proliferation

7. Cell Proliferation versus Cell Differentiation

8. Other Related Aspects of Cell Proliferation Control

Growth Regulators Coordinate Proliferation of Plant Cells

Cryopreservation Enhances Cell Proliferation

Molecular Regulation of Cell Proliferation and Differentiation

Conclusion and Future Outlooks

Chapter VI: Cell Proliferation in Drug Discovery and Development

2. The Application of MTS Colorimetric Assay for Measurement of Cell Proliferation and Cytotoxicity

2.1. MTS Colorimetric Assay Introduction

2.2. Cytokines and Cell Proliferation.

2.3. Immunotoxins and Cell Proliferation

2.4. Targeted Cell-Selective Cytolysis and Gene Therapy

3. Real-time Dynamic Cell Growth Monitoring

3.1. Real-time Cell Electronic Sensing (RT-CES)

3.2. RT-CES Application for Cytoxicity of Immunotoxins

3.3. RT-CES and Selective Cytolysis with Tropism-modified Adenoviral Vectors

4. Signal Transduction and Cell Proliferation (Reporter Gene Assays)

4.1. STAT3 Luciferase Reporter Gene Assay

Chapter VII: Cell Adhesion and Proliferation on Polymeric Biomaterials for Tissue Engineering

1.1. The history of Biomaterial Development

1.2. Parameters for Biomaterial Research

1.3. The Advantage of Synthetic Polymeric Biomaterials

2. The Synthesis of Polymeric Biomaterials and the Effects on Cell Adhesion and Proliferation

2.1. The Design of Polymer Molecular Structure

2.2. The Incorporating of Bioactive Molecules

3. The Surface Modification of Polymeric Biomaterials and the Effect on Cell Adhesion and Proliferation

3.1. Surface Topographical Strategy and Its Application

3.2. Surface Chemical Strategy and Its Application

4. The Bulk Modification of Polymeric Biomaterials and the Effect on Cell Adhesion and Proliferation

4.1. Composites and Their Application in Bone Tissue Engineering

4.2. Bulk Modification with Bioactive Molecules

5. The Geometry of 3D Scaffolds and the Effect on Cell Adhesion and Proliferation in Bone Tissue Engineering

5.1. Porosity and PoreSize

5.2. Interconnected Channels

Index.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

ISBN:

1-62417-402-7

OCLC:

923663875