Endocrine manifestations of systemic autoimmune diseases / edited by Sara E. Walker, Luis J. Jara.

Format:

Book

Contributor:

Walker, Sara E.

Jara, Luis J., 1948-

Series:

Handbook of systemic autoimmune diseases ; v. 9.

Handbook of systemic autoimmune diseases, 1571-5078 ; v. 9

Language:

English

Subjects (All):

Autoimmune diseases--Endocrine aspects.

Autoimmune diseases.

Physical Description:

xvii, 330 p., [3] p. of plates : ill, 1 map.

Edition:

1st ed.

Place of Publication:

Amsterdam : Elsevier, 2008.

Language Note:

English

Summary:

This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics. *The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy *The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis

Contents:

Cover

EndocrineManifestations of Systemic Autoimmune Diseases

Copyright page

Preface

Series Editor

Volume Editors

List of Contributors

Contents

Part I: Pathophysiology

Chapter 1. Neuroendocrine Immune Control Mechanisms and their Influence on Autoimmune Disease

1. Introduction

2. Systemic neuroendocrine alterations

3. Local neuroendocrine alterations in the inflamed synovium

4. Conclusions

References

Chapter 2. Sex Hormones, the Immune System and Autoimmune Diseases

1. Sex hormones and autoimmune diseases

2. Peripheral sex hormone metabolism in autoimmune diseases

3. Immunomodulation by sex hormones

Chapter 3. Gender Bias in Murine Lupus*

2. The female sex hormones in the pathogenesis of lupus

3. Male sex hormones in the pathogenesis of lupus

4. Gender-associated genetic factors and lupus

5. Genetic factors and the responsiveness to sex hormones in lupus

6. Conclusions

Chapter 4. Role of Prolactin in Autoimmune Diseases

2. PRL and the neuroendocrine-immune network

3. Prolactin receptors

4. PRL and immune system

5. PRL on Th1/Th2 balance in autoimmune diseases

6. Prolactin and autoimmune diseases

7. Hyperprolactinemia in non-organ-specific autoimmune diseases

8. Other non-organ-specific autoimmune diseases

9. Hyperprolactinemia in organ-specific autoimmune diseases

Chapter 5. The Pathogenesis of Type 1 Diabetes

2. Classification of diabetes

3. Models for the development of T1D

4. Immunology of T1D

5. Markers of the autoimmune process

6. Stages for diabetes development

7. Conclusion

Chapter 6. The Genetics of Autoimmune Thyroid Diseases

2. Epidemiological data.

3. Identifying complex disease genes

4. Immune-regulatory genes

5. Thyroid-specific genes

Chapter 7. Thyroid Dysfunction and the Immune System

1. Physiological interactions of thyroid function and the immune system

2. The thyroid gland as a target of autoimmune disease

Part II: Clinical Aspects

Chapter 8. Autoimmunity and the Pituitary Gland

2. Pathophysiology

3. Anti-pituitary antibodies

4. Lymphocytic hypophysitis

5. Conclusions

Chapter 9. Adrenal Involvement in Systemic Autoimmune Diseases

2. Adrenal involvement in SLE

3. Adrenal involvement in APS

4. Adrenal involvement in Sjögren's syndrome

5. Adrenal involvement in systemic sclerosis

6. Adrenal involvement in giant cell arteritis and polymyalgia rheumatica

7. Adrenal involvement in other autoimmune diseases

Chapter 10. Endometriosis and Autoimmunity

2. Etiology and pathogenesis

3. Immunological abnormalities

Chapter 11. Autoimmunity in Turner's, Down's, and Klinefelter's Syndromes

2. Clinical manifestations of Turner's, Down's, and Klinefelter's syndrome

3. Genetics of chromosomal disorders

4. Mechanisms of autoimmunity

5. Autoimmune disease in Turner's syndrome

6. Autoimmune disease in Klinefelter's syndrome

7. Autoimmune disease in Down's syndrome

8. Possible mechanisms for autoimmunity in chromosomal abnormalities

Chapter 12. Autoimmune Polyendocrine Syndromes (APS) or Multiple Autoimmune Syndromes (MAS)

1. Historical considerations in autoimmune disorders of the endocrine glands

2. Autoimmune polyendocrine syndromes or multiple autoimmune syndromes

3. Conclusions

Acknowledgments

References.

Chapter 13. Endocrine Manifestations of the Antiphospholipid Syndrome

2. Results

3. Summary

Chapter 14. Autoantibodies and Infertility in Autoimmune Diseases

2. Autoimmune conditions associated with infertility

3. Autoantibodies associated with infertility

4. Drugs used for autoimmunity and their effects on fertility

Chapter 15. Systemic Lupus Erythematosus and Endocrine Disorders

2. Thyroid disease

3. Parathyroid gland

4. Adrenal gland

5. Diabetes

6. Hyperprolactinemia

7. Hypogonadism/Klinefelter's syndrome

8. ADH and SLE

9. Metabolic profile

10. Conclusions

Chapter 16. Pregnancy, Hormones, and Autoimmune Rheumatic Diseases

2. Hormones, the immune system, and pregnancy

3. Systemic lupus erythematosus

4. Rheumatoid arthritis

5. Future directions

6. Antiphospholipid antibody syndrome

7. Future directions

8. Conclusion

Chapter 17. Autoimmune Hypothyroidism and Hyperthyroidism in Systemic Autoimmune Disease

1. Systemic lupus erythematosus

2. Sjögren's syndrome

3. Rheumatoid arthritis

4. Scleroderma

5. Dermato/polymyositis

6. Antiphospholipid syndrome

Chapter 18. Type 1 Diabetes Mellitus at the Crossroad of Polyautoimmunity

2. T1D is a predictable autoimmune disease

3. T1D and other autoimmune diseases (ADs)

Part III: Hormonal Modulation in the Therapy of Autoimmune Diseases

Chapter 19. Estrogen in Systemic Lupus Erythematosus: Lessons from the SELENA Study

1. Estrogens in SLE

2. Menstrual function in SLE

3. Oral contraceptive use in SLE

4. Hormone replacement therapy (HRT) in SLE.

5. Cyclophosphamide in SLE and risk of ovarian failure

6. Dehydroepiandrosterone (DHEA)

7. Summary

Chapter 20. Hormonal Modulation of Autoimmune Diseases: Glucocorticoids

2. Mechanisms of glucocorticoid actions

3. The hypothalamic-pituitary-adrenal (HPA) axis in chronic autoimmune diseases

4. Therapeutic use of glucocorticoids

5. Adverse events of glucocorticoids

Chapter 21. Estrogen and Prolactin: Contributions to Autoimmunity in Murine Models of Systemic Lupus Erythematosus

1. Effects of estrogen in murine models of lupus

2. Immunologic imprinting of the fetus

3. Estrogen receptors in murine lupus

4. Diet therapy for murine lupus

5. Hormone manipulation to treat murine™SLE

6. Effects of prolactin on the immune system

7. Estrogen-prolactin interactions

8. Prolactin in murine models of SLE

Chapter 22. Dehydroepiandrosterone

2. Conversion of dehydroepiandrosterone to downstream steroid hormones

3. Dehydroepiandrosterone in inflammation

4. Role of dehydroepiandrosterone in bone homeostasis

Chapter 23. Glucocorticoid Therapy for Polymyalgia Rheumatica

2. Treatment

Chapter 24. Danazol Therapy

1. Danazol in the management of autoimmune diseases

2. Side effects of danazol therapy

Part IV: Novel Therapies

Chapter 25. Islet Transplantation for the Treatment of Type I Diabetes

1. Historical perspectives on islet transplantation

2. Current procedures for islet isolation and transplantation

3. Islets and pancreas transplantation

4. Immunosuppression

5. Risks and side effects

6. Islet graft monitoring

Chapter 26. The Immunoendocrine Role of Vitamin D in Autoimmunity

1. The effect of vitamin D on immune system components

2. Antigen-presenting cells

3. Evidence of vitamin D receptor role in™autoimmunity

4. Vitamin D deficiency and autoimmune diseases

5. Thyroiditis

Chapter 27. Modulation of Hormone Axes by Anti-TNF Therapy

2. The role of tumor necrosis factor in arthritis

3. Hypothalamic-pituitary-adrenal axis

4. Hypothalamic-pituitary-gonadal axis

5. Hypothalamic-pituitary-liver-muscle axis

6. Adipose tissue and hormones of the HPA axis

7. The nervous system

8. Conclusions

Subject Index

Colour plate.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

ISBN:

0-08-055932-8

1-281-27965-X

0-444-53172-6

OCLC:

476156515