Stem cell repair and regeneration. Volume 3 / editors, Nagy A. Habib ... [et al.].

Format:

Book

Contributor:

Habib, Nagy A.

Series:

Hammersmith series ; 3.

Hammersmith series ; 3

Language:

English

Subjects (All):

Stem cells.

Stem cells--Research.

Stem cells--Transplantation.

Transplantation of organs, tissues, etc.

Physical Description:

1 online resource (318 p.)

Edition:

1st ed.

Place of Publication:

London : Imperial College Press ; Hackensack, NJ : Distributed by World Scientific Publishing, c2008.

Summary:

Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. The third book in the Stem Cell Repair and Regeneration series offers contributions from numerous areas bridging medicine and the life sciences. Significant research activities in the tissue engineering or regenerative medicine (the term recently used) field started in the 1970's, and there is currently great excitement over the possibility of replacing damaged body parts through regenerative medicine. Potential strategies to replace, repair and restore the function of damaged tissues or...

Contents:

Contents; Contributors; Preface; Chapter 1. The Biology of Human Mesenchymal Stem Cells Claire Westwood and Mark O. Clements; Introduction; Historical Perspective; Differentiation Potential of Bone Marrow-Derived MSCs; Adipocytes, osteoblasts, chondrocytes and hematopoiesis-supportive stroma; Tenocytes; Cardiac and skeletal muscle cells; Hepatocytes; Neural; In vivo differentiation potential; Isolation of MSCs from Site Other Than the Bone Marrow; Multipotent Adult Progenitor Cells; MSC Cell Surface Markers; Self-Renewal of MSCs

Signaling Pathways Involved in MSC Proliferation and Differentiation Conclusion; References; Chapter 2. Mesenchymal Stem Cells: From Culture to Clinic Carl A. Gregory; Introduction; Acquisition and Expansion of MSCs; MSCs for Regenerative Medicine; Modulation of the Immune Response by MSCs; MSCs as Vectors for Gene Therapy; Concluding Remarks; References; Chapter 3. Stem Cell Bioprocessing for Clinical Applications of Regenerative Medicine Athanaslos Mantalaris, Wesley L. Randle and Julia M. Polak; Introduction; Design Principles; Cells; Materials; Bioprocess characterization

Bioprocess monitoring and control Bioreactors; Conclusions; References; Chapter 4. Defining and Overcoming the Immunological Barriers to Stem Cell Therapies Nathan J. Robertson, Herman Waldmann and Paul J. Fairchild; Introduction; The Hurdles of the Immune System; How High are the Hurdles? Immunogenicity of ES Cells and Derivatives; Expression of blood group antigens; Expression of MHC Class I and MHC Class II; The role of passenger APC; Immune privilege; Sidestepping the Hurdles; Patient-specific cell lines; ES cell banking; Genetic manipulation; Jumping the Hurdles: Immune Tolerance...

Conclusion Acknowledgements; References; Chapter 5. Activation of the Immune System: A Corollary of Transplantation with ES Cell-Derived Tissues Ashleigh S. Boyd, Douglas C. Wu and Kathryn J. Wood; Introduction; How Immunogenic are Stem Cell-Derived Transplants?; The major histocompatibility complex; Minor histocompatibility antigens; Allorecognition and T cell activation; Allorecognition and T cell activation; MHC expression by stem cells; Mechanisms of Immune Attack on ES Cell-Derived Transplants; Innate immunity; Pathogen recognition in innate immune responses; Adaptive immunity...

Modulation of the Immune Response: Approaches to Prevent Rejection Immunosuppression; Tolerance; Genetic engineering of stem cells; Immune subterfuge: transplantation into immune-privileged areas; ES cell nuclear transfer and parthenogenesis; Concluding Remarks; References; Chapter 6. Suppression of HLA Expression by Lentivirus-Mediated Gene Transfer of siRNA Cassettes Noriyuki Kasahara; Introduction; Immunogenicity: A Problem Even for hESC-Derived Transplants; Allograft Rejection is Mediated by Immunorecognition of MHC Antigens; HLA Down-Regulation as a Novel Immunoevasion Strategy

Application of siRNA-Based Methods for Knockdown of HLA Expression

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611869496

9781281869494

128186949X

9781860949814

1860949819

OCLC:

879025574