A mathematical approach to multilevel, multiscale health interventions : pharmaceutical industry decline and policy response / Rodrick Wallace, Deborah Wallace, Columbia University, USA.

Format:

Book

Author/Creator:

Wallace, Rodrick.

Wallace, Deborah, author.

Series:

Gale eBooks

Language:

English

Subjects (All):

Drug development.

Drugs--Research.

Drugs.

Drugs--Design--Mathematical models.

Medical geography.

Physical Description:

1 online resource (xi, 225 pages)

Edition:

1st ed.

Place of Publication:

London : Imperial College Press, 2013.

London : Imperial College Press, [2013]

Language Note:

English

Summary:

This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mu

Contents:

Preface; Contents; 1. BEYOND MAGIC BULLETS; 1.1 The Pharmaceutical Catastrophe; 1.2 A New Perspective; 1.3 Cognition as `Language'; 1.4 The Human Cognome; 2. EXPANDING THE THEORY; 2.1 No Free Lunch; 2.2 Multiple Broadcasts, Punctuated Detection; 2.3 Metabolic Constraints; 2.4 Environmental Signals; 3. DYNAMIC `REGRESSION' MODELS; 3.1 The Simplest Approach; 3.2 A Rate Distortion Reformulation; 3.3 Multiple Time Scales; 3.4 Incoming Information; 3.5 Pathologies; 3.6 Refining the Model; 4. AN EVOLUTIONARY EXCURSION; 4.1 Introduction; 4.2 Ecosystems as Information Sources; 4.3 Genetic Heritage

4.4 Gene Expression4.5 Interacting Information Sources; 4.6 Conclusions; 5. EXAMPLE: MENTAL DISORDERS; 5.1 Introduction; 5.2 Two Classes; 5.3 Global Broadcast Models; 5.4 Gene Expression; 5.5 Summary; 6. EXAMPLE: PROTEIN FOLDING; 6.1 Introduction; 6.2 Spontaneous Symmetry Breaking; 6.3 A Formal Approach; 6.4 The Energy Picture; 6.5 The Developmental Picture; 6.6 A Comprehensive Treatment; 6.7 Aging and Protein Folding; 6.8 Summary; 7. EXAMPLE: GLYCOME DETERMINANTS; 7.1 Introduction; 7.2 Stochastic Topology; 7.3 The Glycomic Conundrum; 7.4 Another Cognitive Paradigm

7.5 Regulating Glycan Determinants7.6 Glycan Spectra; 7.7 Summary; 8. EXAMPLE: GLYCAN/LECTIN LOGIC GATES; 8.1 Introduction; 8.2 The Critical Exponent; 8.3 Two Examples; 8.4 Information Catalysis; 8.5 A Tiling Symmetry Model; 8.6 Summary; 9. EXAMPLE: IDP LOGIC GATES; 9.1 Introduction; 9.2 Symbolic Dynamics of Molecular Switching; 9.3 Another Dual Information Source; 9.4 Information Catalysis; 9.5 Summary; 10. TREATMENT; 10.1 The Generalized Retina; 10.2 Therapeutic Efficacy; 10.3 Psychosocial Stress; 10.4 Flight, Fight, and Helplessness; 10.5 Institutions as Niche Construction

10.6 The Hall of Mirrors10.7 Side Effects Reconsidered; 11. HISTORY AND HEALTH; 11.1 Malaria and the Fulani; 11.2 The American Catastrophe; 12. BEYOND GLASPERLENSPIEL; 13. MATHEMATICAL APPENDIX; 13.1 The Tuning Theorem; 13.2 The Rate Distortion Theorem; 13.3 Stochastic Differential Equations; 13.4 Morse Theory; 13.5 Groupoids; 13.6 `Biological' Renormalization; 13.7 Large Deviations; Bibliography; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

ISBN:

9781299462168

1299462162

9781848169975

1848169973

OCLC:

838790821