Iron metabolism : from molecular mechanisms to clinical consequences / Robert Crichton.

Format:

Book

Author/Creator:

Crichton, Robert R., author.

Series:

THEi Wiley ebooks.

Language:

English

Subjects (All):

Iron--Metabolism.

Iron.

Iron proteins.

Iron--Metabolism--Disorders.

Physical Description:

1 online resource (910 pages)

Edition:

Fourth edition.

Place of Publication:

Chichester, West Sussex : John Wiley and Sons, Incorporated, 2016.

Language Note:

English

System Details:

Access using campus network via VPN at home (THEi Users Only).

Summary:

Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4 th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Contents:

Title Page; Table of Contents; Preface; References; 1 Solution Chemistry of Iron; 1.1 Iron Chemistry; 1.2 Interactions of Iron with Dioxygen and Chemistry of Oxygen Free Radicals; 1.3 Hydrolysis of Iron Salts; 1.4 Formation and Characterisation of Ferrihydrite; 1.5 Ageing of Amorphous Ferrihydrite to more Crystalline Products; 1.6 Biomineralisation; 1.7 Magnetite Biomineralisation by Magnetotactic Bacteria; References; 2 The Essential Role of Iron in Biology; 2.1 Introduction: Iron an Essential Element in Biology; 2.2 Physical Techniques for the Study of Iron in Biological Systems

2.3 Classes of Iron Proteins; 2.4 Haemoproteins; 2.5 Iron-Sulphur Proteins; 2.6 Non-haem, Non-Fe-S Proteins; 2.7 The Dark Side of Iron: ROS, RNS and NTBI; References; 3 Microbial Iron Uptake; 3.1 Introduction; 3.2 Iron Uptake from Siderophores; 3.3 Fe2+ transport Systems; 3.4 Iron Release from Siderophores in the Cytoplasm; 3.5 Intracellular Iron Metabolism; 3.6 Control of Gene Expression by Iron; References; 4 Iron Acquisition by Pathogens; 4.1 Introduction; 4.2 Host Defence Mechanisms, Nutritional Immunity; 4.3 Pathogenicity and PAIs; 4.4 Pathogen-specific Iron Uptake Systems

4.5 Role of Fur and Fur Homologues in Virulence; 4.6 Role of Pathogen ECF Sigma Factors; 4.7 Fungal Pathogens; References; 5 Iron Uptake by Plants and Fungi; 5.1 Iron Uptake by Plants; 5.2 Iron Metabolism and Homeostasis in Plants; 5.3 Iron Uptake, Metabolism and Homeostasis in Fungi; References; 6 Cellular Iron Uptake and Export in Mammals; 6.1 The Transferrins; 6.2 Cellular Iron Uptake; 6.3 Cellular Iron Export; References; 7 Mammalian Iron Metabolism and Dietary Iron Absorption; 7.1 An Overview of Mammalian Iron Metabolism; 7.2 Mammalian Iron Absorption

7.3 Molecular Mechanisms of Mucosal Iron Absorption; References; 8 Intracellular Iron Utilisation; 8.1 Intracellular Iron Pools; 8.2 Mitochondrial Iron Metabolism; 8.3 Haem Oxygenase; References; 9 Iron Storage Proteins; 9.1 Introduction; 9.2 The Ferritin Superfamily and Haemosiderins; 9.3 Iron Uptake and Release from Ferritin; 9.4 Biotechnological Applications of Ferritins; References; 10 Cellular and Systemic Iron Homeostasis; 10.1 Cellular Iron Homeostasis; 10.2 Systemic Iron Homeostasis; 10.3 Integration of iron homeostatic systems; References; 11 Iron Deficiency, Iron Overload and Therapy

11.1 Iron-deficiency Anaemia (IDA); 11.2 Hereditary Iron Overload; 11.3 Acquired Iron Overload; References; 12 Iron and Immunity; 12.1 Introduction; 12.2 The key role of macrophages; 12.3 Effect of Iron Status on Phagocytic Cell Function; 12.4 Effect of Phagocytic Cell Function on Iron Metabolism; 12.5 Effector Molecules of the Innate Immune System; 12.6 Adaptive immunity; 12.7 Immune Function and other Factors; 12.8 Concluding remarks; References; 13 Iron and Oxidative Stress; 13.1 Oxidative stress; References; 14 Interactions between Iron and other Metals; 14.1 Introduction; 14.2 Iron Interactions with Essential Metals

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781118925638

1118925637

9781118925621

1118925629

OCLC:

945170131