Optimization methods in metabolic networks / Costas D. Maranas, Ali R. Zomorrodi.

Format:

Book

Author/Creator:

Maranas, Costas D., author.

Zomorrodi, Ali R., author.

Language:

English

Subjects (All):

Metabolism--Regulation.

Metabolism.

Metabolism--Testing.

Physical Description:

1 online resource (281 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley, 2016.

Summary:

Provides a tutorial on the computational tools that use mathematical optimization concepts and representations for the curation, analysis and redesign of metabolic networks * Organizes, for the first time, the fundamentals of mathematical optimization in the context of metabolic network analysis * Reviews the fundamentals of different classes of optimization problems including LP, MILP, MLP and MINLP * Explains the most efficient ways of formulating a biological problem using mathematical optimization * Reviews a variety of relevant problems in metabolic network curation, analysis and redesign with an emphasis on details of optimization formulations * Provides a detailed treatment of bilevel optimization techniques for computational strain design and other relevant problems

Contents:

Mathematical optimization fundamentals

Linear programming and duality theory

Flux balance analysis and LP problems

Modeling with binary variables and MILP

Thermodynamic analysis of metabolic networks

Resolving network gaps and growth prediction inconsistencies in metabolic networks

Identification and construction of pathways to target metabolites

Computational strain design

NLP fundamentals

NLP applications in metabolic networks

MINLP fundamentals and applications.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781119189015

1119189012

9781119188919

1119188911

OCLC:

935255323