Signaling pathways in liver diseases / [edited by] Jean-François Dufour, Pierre-Alain Clavien.

Format:

Book

Contributor:

Dufour, Jean-François (Professor of hepatology), editor.

Clavien, Pierre-Alain, editor.

Language:

English

Subjects (All):

Liver Diseases--Pathophysiology.

Liver Diseases.

Liver--cytology.

Liver.

Cellular signal transduction.

Physical Description:

1 online resource (520 p.)

Edition:

Third edition.

Place of Publication:

Chichester, West Sussex, UK ; Hoboken, NJ, USA : John Wiley & Sons, Ltd, 2016.

Language Note:

English

Summary:

Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing a

Contents:

Title Page; Copyright Page; Contents; List of Contributors; Chapter 1 Hepatocytes; Introduction; Liver and hepatocyte development; Phenotype and regeneration of the mature hepatocyte; Metabolic functions of the liver; Resorption, storage, and synthesis; Detoxification and excretion; Detoxification of specific substances; Excretion; Multiple choice questions; References; Chapter 2 Signaling pathways in biliary epithelial cells; Introduction; Membrane receptors; Cyclic adenosine 3', 5'-monophosphate (cAMP); Cytosolic Ca2+; Protein kinase C; Mitogen-activated protein kinase signaling

Phosphotidylinositol 3-kinase signaling Notch signaling; Hedgehog signaling; Vascular endothelial growth factor; Pathological conditions; Conclusion; Acknowledgments; Multiple choice questions; References; Chapter 3 Stellate cells; Polypeptide growth factor receptors; Transforming growth factor-β receptor superfamily; Seven transmembrane domain receptors; Chemokines; Tumor necrosis factor receptor superfamily; Nuclear receptor family; Other cytokine receptors; Adipokine receptors; Extracellular matrix signaling and hepatic stellate cells; Toll-like receptors; Cannabinoid receptors

Hedgehog pathway Wnt pathway; Autophagy; Senescence of activated stellate cells; miRNAs and hepatic stellate cells; Conclusion; Multiple choice questions; References; Chapter 4 Kupffer cells; Introduction; Markers, origin, and heterogeneity of Kupffer cells; M1 versus M2 polarization in Kupffer cells; Lipopolysaccharide signaling and endotoxin tolerance; Experimental approaches to deplete Kupffer cells in vivo; Role of Kupffer cells in liver disease; Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis; Alcoholic liver disease; Liver regeneration; Liver fibrosis and cirrhosis

Ischemia-reperfusion liver injury Primary and metastatic liver tumors; Infectious diseases; Clinical applications and future perspectives; Acknowledgment; Multiple choice questions; References; Chapter 5 Hepatic sinusoidal endothelial cells; Development and structure; Cellular functions; Filtration via fenestrae; Diapedesis; Nitric oxide signaling; Endocytosis; Bacterial processing; Liver regeneration; Pathobiology; Fibrosis and cirrhosis; Alcoholic liver disease; Nonalcoholic fatty liver disease; Hepatic malignancies; Drug toxicity; Ischemia-reperfusion injury; Aging process; Conclusion

Multiple choice questions References; Chapter 6 Extracellular matrix; Introduction; Components of the extracellular matrix in liver (Figure 6.1); The collagen scaffold; Proteoglycans; Laminin; Fibronectin; Matricellular proteins; Changes in the extracellular matrix from normal to fibrotic liver; Pathways of cell-matrix interaction; Integrin family; ADAM molecules; Discoidin domain receptors; Growth factors in ECM (Figure 6.4); The extracellular matrix and the stem cell niche; Metalloproteinases and their inhibitors; Conclusion; Multiple choice questions; References

Chapter 7 Platelets: a new cell type in liver physiology

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781118663387

1118663381

9781118663356

1118663357

9781118663363

1118663365

OCLC:

923714010