Diseases of importance in the United States / by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine.

Format:

Book

Contributor:

Institute of Medicine (U.S.). Committee on Issues and Priorities for New Vaccine Development.

National Institute of Allergy and Infectious Diseases (U.S.)

Series:

New vaccine development : establishing priorities ; v. 1

Language:

English

Subjects (All):

Vaccines--Research--Government policy.

Vaccines.

Vaccination--United States.

Vaccination.

Vaccination--Developing countries.

Physical Description:

1 online resource (472 pages)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1985.

Language Note:

English

Contents:

""Title""; ""Copyright""; ""Acknowledgments""; ""Preface""; ""Abstract""; ""Contents""; ""1 Summary""; ""Selection of Candidates""; ""Determination of Health Benefits""; ""Disease Burden Estimates""; ""Infant Mortality Equivalence Values""; ""Total Disease Burden Values""; ""Vaccine Characteristics""; ""Predictions of Vaccine Development""; ""Definition of Probable Vaccine Target Population""; ""Estimation of Vaccine Utilization""; ""Estimation of Time to Licensure, Time to vaccine Adoption, and Delay of Vaccination Benefits: Discounting""; ""Estimation of vaccine Preventable Illness""

""Calculation of Expected Health Benefits for Each Vaccine"" ""Cost Calculations""; ""Calculation of Morbidity Costs Averted by the Vaccine""; ""Vaccination Program Costs""; ""Integration of Costs""; ""Interpretation of Health Benefit and Net Cost Rankings""; ""Findings, Conclusions, Recommendations""; ""Recommendation""; ""Reference""; ""2 Priority Setting for Health Related Investments: A Review of Methods""; ""Methods for Project Ranking and Selection""; ""Multiattribute Accounting""; ""Multiattribute Scoring""; ""Decision Analysis With Multiple Objectives""

""Cost-Effectiveness and Cost-Utility Analysis"" ""Benefit-Cost Analysis""; ""Selection of an Approach""; ""Issues in Project Ranking Methodologies""; ""Sources of Estimates""; ""Sequential or 'Lexicographic' Methods""; ""Interdependence Among Projects""; ""The 'Portfolio' Question""; ""Summary""; ""References""; ""3 Overview of the Analytic Approach""; ""Method""; ""Interpretation of Results""; ""Guidelines""; ""Definition of Dominance""; ""Step 1""; ""Step 2""; ""Step 3""; ""Step 4""; ""Summary""; ""4 Comparison of Disease Burdens and Costs""

""Elements of the System for Comparing Morbidity and Mortality Burdens Arising From various Diseases"" ""Trade-Off Values""; ""Expression of Morbidity and Mortality Burdens""; ""Procedures Used in Deriving Disease Estimates""; ""Limitations of the Current Estimates""; ""Value Judgments in Quantifying Morbidity and Mortality""; ""IME Perspectives used in This Study""; ""The Effect of Adopting Other IME Perspectives""; ""Comparison of Direct Costs Resulting from Diseases""; ""Scope of Cost Calculations""; ""Procedures""; ""Findings""; ""Limitations of the Proposed System""

""Summary and Conclusions"" ""Recommendations""; ""References""; ""5 Predictions on Vaccine Development""; ""The Need for Predictions""; ""Selection of Candidates""; ""Vaccine Candidates and Target Populations""; ""Predictions on Vaccine Development""; ""Probability of Successful Development""; ""Cost of Development""; ""Time to Licensure""; ""Comments""; ""Predictions on Vaccine Characteristics""; ""Efficacy""; ""Adverse Reactions""; ""Production Technology, Delivery Requirements, and Cost/Dose""; ""Number of Doses and Route of Administration""; ""Conclusions""; ""6 Assessing the Likely Utilization of New Vaccines""

Notes:

Prepared for the National Institute of Allergy and Infectious Diseases.

Includes bibliographical references and index.

ISBN:

1-281-30039-X

9786611300395

0-309-11575-2

OCLC:

923278682