Matrix metalloproteinase biology / edited by Irit Sagi, Jean P. Gaffney.

Format:

Book

Contributor:

Sagi, Irit, editor.

Gaffney, Jean P., editor.

Language:

English

Subjects (All):

Metalloproteinases--Laboratory manuals.

Metalloproteinases.

Metalloproteins--Research--Methodology.

Metalloproteins.

Physical Description:

1 online resource (253 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley-Blackwell, 2015.

Language Note:

English

Summary:

Discussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, Matrix Metalloproteinase Biologyis a collection of chapters written by leaders in the field of MMPs. The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases. The text first

Contents:

Matrix metalloproteinases : from structure to function / Maciej J. Stawikowski and Gregg B. Fields

Dynamics and mechanisms of substrate recognition by matrix metalloproteinases / Ivan E. Collier and Gregory Goldberg

Matrix metalloproteinases : structure and dynamics in substrates recognition and processing / Marco Fragai, Claudio Luchinat

Metzincin modulators : beyond the active site / Dmitriy Minond

Therapeutics targeting matrix metalloproteinases / Jillian Cathcard, Ashleigh Pulkoski-Gross, Stanley Zucker, and Jian Cao

Matrix metalloproteinases : modification of extracellular matrix-medicated signaling / Howard C. Crawford and M. Sharon Stack

Meprin and Adam metalloproteinases : two sides of the same coin? / Christopher Becker-Pauly and Stefan Rose-John

Metalloproteinases in innate immunity and disease / Antoine Dufour and Christopher Overall

MMPS : from genomics to degradomics / Barbara Grünwald, Pascal Schlage, Achim Krüger, and Ulrich auf dem Keller

Biology and clinical significance of MMPS / Di Jia, Roopali Roy, and Marsha A. Moses.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9781118772386

1118772385

9781118772287

1118772288

OCLC:

900159220