Multicomponent reactions : concepts and applications for design and synthesis / edited by Raquel P. Herrera, Eugenia Marques-Lopez ; contributors Juan V. Alegre-Requena [and seventeen others].

Format:

Book

Contributor:

Herrera, Raquel P., 1977- editor.

Marques-Lopez, Eugenia, 1978- editor.

Alegre-Requena, Juan V., contributor.

Language:

English

Subjects (All):

Chemical reactions.

Catalysis.

Chemistry, Organic.

Physical Description:

1 online resource (526 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley, 2015.

Language Note:

English

Summary:

Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multi-component reactions - including key routes for synthesizing complex molecules. Illustrates the crucial role and the important utility of multi-component reactions (MCRs) to organic syntheses; Compiles novel and efficient synthetic multi-component procedures to give readers a complete picture of this class of organic reactions Helps readers to design efficient and practical transformations using multicomponent reaction strategies; Describes reaction background,

Contents:

""Title Page""; ""Copyright Page""; ""Contents""; ""List of Contributors""; ""Preface""; ""List of Abbreviations""; ""Chapter 1 Introduction: Multi-component Strategies""; ""General Introduction""; ""1.1 Basic Concepts""; ""1.1.1 Clarifying Terminology: One-Pot, Domino/Cascade, Tandem, and MCRs""; ""1.1.2 Using Rational Design to Discover New MCRs""; ""1.1.3 Discovering New MCRs with Automated Combinatorial Reaction Finding""; ""1.1.4 Computational and Analytical Tools to Study MCRs""; ""1.1.5 Diversity-Oriented Synthesis and Biology-Oriented Synthesis""; ""1.1.6 Optimization of MCRs""

""1.2 Catalysis in MCRs and Various Synthetic Approaches""""1.2.1 Organocatalysis in MCRs""; ""1.2.2 Organometallic Catalysis in MCRs""; ""1.2.3 Biocatalysis in MCRs""; ""1.2.4 Combining Different Types of Catalysis""; ""1.2.5 Other Methods""; ""1.3 Green Chemistry""; ""1.3.1 Atom Economy""; ""1.3.2 Using Green Solvents""; ""1.3.3 Solventless MCRs""; ""1.3.4 Heterogeneous Catalysis in MCRs""; ""1.4 Importance and Evolution""; ""References""; ""Chapter 2 Organocatalytic Asymmetric Multicomponent Reactions""; ""2.1 Introduction""; ""2.2 Three-Component Mannich Reaction""

""2.3 Cycloaddition Reaction""""2.4 Organocatalytic Multicomponent Domino Asymmetric Reactions""; ""2.4.1 Michael-Type Multicomponent Process: Cyclic Carbon Frameworks""; ""2.4.2 Miscellaneous Domino Reactions""; ""2.5 Development of Drug Intermediates""; ""2.6 Miscellaneous Reaction""; ""2.7 Conclusions""; ""References""; ""Chapter 3 Metal-Catalyzed Multicomponent Reactions""; ""3.1 Introduction""; ""3.2 Palladium-Catalyzed MCRs""; ""3.2.1 Palladium-Catalyzed Carbonylation Reactions""; ""3.2.2 Palladium-Catalyzed MCRs Involving Isocyanides""

""3.2.3 Carbopalladation of Unsaturated C�C π-Components""""3.2.4 Amines as Building Blocks""; ""3.3 Nickel-Catalyzed MCRs""; ""3.3.1 Nickel-Catalyzed Cross-Trimerization of Alkynes""; ""3.3.2 Nickel-Catalyzed π-Systems Couplings""; ""3.3.3 Ni-Catalyzed Reductive Conjugate Addition""; ""3.4 Group 11 Metal-Catalyzed MCRs""; ""3.4.1 Copper-Catalyzed Azide Alkyne Cycloaddition""; ""3.4.2 A3-Coupling""; ""3.4.3 Miscellaneous""; ""3.5 Rhodium-Catalyzed MCRs""; ""3.5.1 Rhodium-Catalyzed Mcrs via Onium Ylide Intermediates""; ""3.5.2 Rhodium-Catalyzed Three-Component Cross-Addition Reactions""

""3.6 Group 8 Metal-Catalyzed MCRs""""3.6.1 Iron-Catalyzed MCRs""; ""3.6.2 Ruthenium-Catalyzed MCRs""; ""3.7 Conclusions""; ""References""; ""Chapter 4 Multicomponent Reactions with Organoboron Compounds""; ""4.1 Introduction""; ""4.2 Catalytic MCRs with Organoboron Compounds""; ""4.2.1 Cobalt-Catalyzed MCRs Containing Organoboron Compounds""; ""4.2.2 Palladium-Catalyzed MCRs Containing Organoboron Compounds""; ""4.3 Multicomponent Assembly of Organoboron Compounds: Efficient Approach to Supramolecular Chemistry""; ""4.4 Multicomponent Petasis-Borono Mannich Reaction""

""4.4.1 Organocatalytic Enantioselective Petasis-Type Reaction""

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781118863978

1118863976

9781118864005

111886400X

9781118863992

1118863992

OCLC:

900278057