The retinoids : biology, biochemistry, and disease / edited by Pascal Dollé and Karen Neiderreither.

Format:

Book

Contributor:

Dollé, Pascal, editor.

Neiderreither, Karen, editor.

Standardized Title:

Retinoids (Dollâe)

Language:

English

Subjects (All):

Retinoids.

Physical Description:

1 online resource (634 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley Blackwell, 2015.

Language Note:

English

Summary:

The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. The book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five parts, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in

Contents:

Title Page; Copyright Page; Contents; Contributors; Preface; Part I Vitamin A Metabolic and Enzymatic Pathways; Chapter 1 Vitamin A Metabolism, Storage and Tissue Delivery Mechanisms; I. Introduction; II. Vitamin A Metabolism Relevant to its Storage; III. Vitamin A Storage; IV. Vitamin A Transport in the Circulation; V. Integration within the Intact Organism of Vitamin A Metabolism, Storage and Transport; Acknowledgments; References; Chapter 2 Assimilation and Conversion of Dietary Vitamin A into Bioactive Retinoids; I. Introduction

II. Dietary Sources of Vitamin A and Provitamin A CarotenoidsIII. Intestinal Absorption and Metabolism of Dietary Vitamin A and Provitamin A Carotenoids; IV. Formation of β-Apocarotenoids; V. Possible Biological Functions of Apocarotenoids; VI. Conclusions and Perspectives; Acknowledgments; References; Chapter 3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets; I. Introduction; II. Multilocular Lipid Droplets; III. The Mitochondrial-Associated Membrane; IV. Birth of Lipid Droplets; V. Lipid Droplets and Retinoid Homeostasis

VI. In the Absence of Lipid Droplets, LRAT and RDH1 Localize with the ER, Whereas CRBP1 and RDH10 Localize with MitotrackerVII. During Acyl Ester Biosynthesis LRAT, CRBP1 and RDH10 Associate with LIPID Droplets; VIII. Lipid Droplet Association Activates RDH10; IX. Lipid Droplet Association Requires the N-termini of LRAT and RDH10; X. Summary; XI. Conclusions and Future Directions; References; Chapter 4 Evolution of the Retinoic Acid Signaling Pathway; I. Introduction; II. An Overview of Chordate Retinoid Metabolism; III. Retinoic Acid Signaling in Chordates

IV. Evolution of Retinoic Acid SignalingV. Conclusions; Acknowledgments; References; Part II Biochemistry and Cellular Biology of Retinoic Acid Signaling; Chapter 5 Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post-Translational and Epigenetic Regulatory Mechanisms; I. Introduction; II. The Basics of Rar Structure; III. Repressive Epigenetic Landscape of Rar Target Genes in the Absence of Retinoic Acid; IV. Reorganization of the Epigenetic Landscape after Retinoic Acid Addition; V. Noncoding RNAs in the Regulation of the Epigenetic Landscape

VI. Back to a Repressive Epigenetic Landscape when Transcription Turns "OFF"VII. Phosphorylation: Another Post-Translational Modification Code Induced by Retinoic Acid; VIII. Two Models for the Activation of RAR Target Genes Via a Sea of Post-Translational Modifications and Epigenetic Changes; IX. Aberrant Epigenics in Cancer: Consequences on the Retinoic Acid Response; X. Conclusion and Future Prospects; References; Chapter 6 Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes; I. Introduction; II. Coregulators OF RARs and RXRs

III. Coregulators in Epigenetic Regulation

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed May 9, 2015).

ISBN:

9781118627907

1118627903

9781118628003

1118628004

OCLC:

908080324