Methods and applications of statistics in clinical trials. Volume 2, Planning, analysis, and inferential methods / edited by N. Balakrishnan.

Format:

Book

Contributor:

Balakrishnan, N., editor.

Series:

Methods and Applications of Statistics

Wiley Series Methods and Applications of Statistics

Language:

English

Subjects (All):

Clinical trials--Statistical methods.

Clinical trials.

Physical Description:

1 online resource (963 p.)

Place of Publication:

Hoboken, New Jersey : Wiley, 2014.

Language Note:

English

Summary:

Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features: Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood metho

Contents:

Cover; Title Page; Copyright Page; Contents; Contributors; Preface; 1 Analysis of Over- and Underdispersed Data; 1.1 Introduction; 1.2 Overdispersed Binomial and Count Models; 1.2.1 Overdispersed Binomial Model; 1.2.2 Overdispersed Poisson Model; 1.2.3 Example; 1.3 Other Approaches to Account for Overdispersion; 1.3.1 Generalized Linear Mixed Model; 1.3.2 Zero-Inflated Models; 1.4 Underdispersion; 1.5 Software Notes; References; 2 Analysis of Variance (ANOVA); 2.1 Introduction; 2.2 Factors, Levels, Effects, and Cells; 2.3 Cell Means Model; 2.4 One-Way Classification; 2.4.1 Example 1

2.5 Parameter Estimation 2.6 The R(.) Notation-Partitioning Sum of Squares; 2.7 ANOVA-Hypothesis of Equal Means; 2.8 Multiple Comparisons; 2.9 Two-Way Crossed Classification; 2.10 Balanced and Unbalanced Data; 2.11 Interaction Between Rows and Columns; 2.12 Analysis of Variance Table; References; 3 Assessment of Health-Related Quality of Life; 3.1 Introduction; 3.2 Choice of HRQOL Instruments; 3.3 Establishment of Clear Objectives in HRQOL Assessments; 3.4 Methods for HRQOL Assessment; 3.5 HRQOL as the Primary End Point; 3.6 Interpretation of HRQOL Results; 3.7 Examples; 3.7.1 HRQOL in Asthma

3.7.2 HRQOL in Seasonal Allergy Rhinitis 3.7,3 Symptom Relief for Late-Stage Cancers; 3.8 Conclusion; Acknowledgment; References; Further Reading; 4 Bandit Processes and Response-Adaptive Clinical Trials: The Art of Exploration Versus Exploitation; 4.1 Introduction; 4.2 Exploration Versus Exploitation with Complete Observations; 4.2.1 The Model of Markov Decision Processes; 4.2.2 The Bandit Processes Under the Bayesian Approach; 4.2.3 The Response-Adaptive Clinical Trials; 4.3 Exploration Versus Exploitation with Censored Observations; 4.4 Conclusion; Acknowledgments.; References

5 Bayesian Dose-Finding Designs in Healthy Volunteers 5.1 Introduction; 5.2 A Bayesian Decision-Theoretic Design; 5.3 An Example of Dose Escalation in Healthy Volunteer Studies; 5.4 Discussion; References; 6 Bootstrap; 6.1 Introduction; 6.2 Plug-In Principle; 6.2.1 How Useful is the Bootstrap Distribution?; 6.2.2 Other Population Estimates; 6.2.3 Other Sampling Procedures; 6.2.4 Other Statistics; 6.3 Monte Carlo Sampling-The ""Second Bootstrap Principle""; 6.4 Bias and Standard Error; 6.5 Examples; 6.5.1 Relative Risk; 6.5.2 Linear Regression; 6.6 Model Stability; 6.6.1 Logistic Regression

6.7 Accuracy of Bootstrap Distributions 6.7.1 Systematic Errors in Bootstrap Distributions; 6.7.2 Bootstrap Distributions Are Too Narrow; 6.8 Bootstrap Confidence Intervals; 6.8.1 t Intervals; 6.8.2 Percentile Intervals; 6.8.3 Bootstrap t; 6.8.4 BCa Intervals; 6.8.5 Bootstrap Tilting Intervals; 6.8.6 Importance Sampling Implementation; 6.8.7 Confidence Intervals for Mean Arsenic Concentration; 6.8.8 Implications for Other Situations; 6.8.9 Comparing Intervals; 6.9 Hypothesis Testing; 6.10 Planning Clinical Trials; 6.10.1 ""What If ' Analyses- Alternate Population Estimates

6.11 How Many Bootstrap Samples Are Needed

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed June 15, 2014).

ISBN:

1-118-59633-1

1-118-59597-1

OCLC:

881416129