Molecular immunotoxicology / edited by Emanuela Corsini and Henk Van Loveren.

Format:

Book

Contributor:

Corsini, Emanuela, editor.

Loveren, Henk Van, editor.

Language:

English

Subjects (All):

Immunotoxicology.

Physical Description:

1 online resource (354 p.)

Edition:

1st ed.

Place of Publication:

Weinheim, Germany : Wiley-VCH, 2014.

Language Note:

English

Summary:

The first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models.Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic e

Contents:

Molecular Immunotoxicology; Contents; Preface; List of Contributors; Chapter 1 The Evolution of Immunotoxicology; 1.1 Introduction; 1.2 Immune-Mediated Environmental Lung Diseases; 1.3 Immunotoxic Drug Reactions; 1.4 Autoimmunity; 1.5 Immunosuppression; 1.6 Allergic Contact Dermatitis (ACD); 1.7 Summary; References; Chapter 2 Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity; 2.1 Introduction; 2.2 Mechanisms of Immunotoxicity; 2.2.1 Interference with Cellular Signaling; 2.2.1.1 Receptor-Mediated Immunotoxicity; 2.2.1.2 Non-receptor-Mediated Immunotoxicity

2.2.2 Adducts Formation and Role of ROS 2.3 Conclusions; References; Chapter 3 Use of Toxicogenomics in Immunotoxicology; 3.1 Introduction; 3.2 Toxicogenomics; 3.2.1 Profiling Gene Expression; 3.2.2 Pathway Arrays; 3.2.3 Comparative Evaluation of Immunotoxicants; 3.2.4 miRNA and siRNA, Gene Expression Regulators; 3.2.5 mRNA Splicing; 3.2.6 RNA-Seq; 3.2.7 Proteomics; 3.2.8 Molecular Genomics; 3.2.9 Phenotypic Anchoring, Dose Response, Time Course; 3.3 Bioinformatics and Data Analysis; 3.3.1 Effect Markers and Machine Learning

3.4 Multiple Omic Approaches in the Evaluation of Immunosuppressive Compounds 3.4.1 Multiple Omic Approaches in the Study of Hypersensitivity; 3.5 Summary and Conclusions; References; Chapter 4 Breakdown of the Molecular Processes Driving the Adverse Outcome Pathways (AOPs) of Skin and Respiratory Sensitization Induction in Humans Exposed to Xenobiotics and Proteins; 4.1 Introduction; 4.2 The AOP for Skin Sensitization; 4.3 The Molecular Processes in the MOA for Sensitization Induction; 4.3.1 Bioavailability: the Compound Acquires Access to the System

4.3.2 Haptenation: the Chemical Reacts Covalently with a ""Carrier Protein""4.3.3 Inflammation: Innate Recognition of Haptens Followed by Activation of Innate Immunity; 4.3.3.1 Haptens Engage Toll-Like Receptors (TLR) 2 and 4; 4.3.3.2 Reactive Oxygen Species (ROS) and Oxidative Stress Play a Role in Chemical Allergen-Induced Skin Cell Activation; 4.3.3.3 Epithelial ROS Production Results in Degradation of Endogenous HA, and TLR2 and TLR4 Activation; 4.3.3.4 ROS Signal the NLRP3 Inflammosome Resulting in IL-1β, IL-18, and IL-33 Activation

4.3.4 Dendritic Cell Activation: from Innate Responses to DC Maturation 4.3.5 Dendritic Cell Migration: Translating the Message into Specific Actions; 4.3.6 T-Cell Priming and Proliferation: the Turning-Point between Sensitization and Effect; 4.4 Summary; References; Chapter 5 Chemical Allergen-Induced Skin Cell Activation; 5.1 Introduction; 5.2 Breaching the Barriers; 5.3 Role of the Extracellular Matrix in Skin Inflammation; 5.4 Cytoprotective Responses and Skin Inflammation; 5.5 Skin Dendritic Cells - Tolerance versus Immunity; 5.6 DC Activation and Migration; 5.7 The Role of Danger Signals

5.8 Inappropriate/Compromised DC Activation

Notes:

Description based upon print version of record.

Includes bibliographical references and index at the end of each chapters.

Description based on online resource; title from PDF title page (ebrary, viewed August 7, 2014).

ISBN:

9783527676996

3527676996

9783527676965

3527676961

9783527676972

352767697X

OCLC:

885020607