Textbook of organ transplantation / editors, Allan D. Kirk [and five others].

Format:

Book

Contributor:

Kirk, Allan, editor.

Language:

English

Subjects (All):

Transplantation of organs, tissues, etc.

Physical Description:

1 online resource (1802 p.)

Edition:

1st ed.

Place of Publication:

Chichester, England : Wiley Blackwell, 2014.

Summary:

Brought to you by the world's leading transplant clinicians, Textbook of Organ Transplantation providesa complete and comprehensive overview of modern transplantation in all its complexity, from basic science to gold-standard surgical techniques to post-operative care, and from likely outcomes to considerations for transplant program administration, bioethics and health policy. Beautifully produced in full color throughout, and with over 600 high-quality illustrations, it successfully: Provides a solid overview of what transplant clinicians/surgeons do, and with topics presented in an order

Contents:

Cover; Title page; Copyright page; Contents; List of Contributors; Volume 1; SECTION 1: History/Introduction; Introduction; CHAPTER 1: A Brief History of Clinical Organ Transplantation; Introduction; The concept of transplant surgery; Transplant biology; Early clinical implementation; The modern era of immune management; Ethical challenges; Summary; References; SECTION 2: Transplantation Biology; Immunology; CHAPTER 2: An Overview of Physiologic Immunity; Introduction; Generalized protective barriers and defense factors; Tissues and organs of the immune system

Cells of the innate and adaptive immune systemInnate immune cells; Granulocytes; Natural killer (NK) cells; Mononuclear phagocytes; Adaptive immune cells; T-cell immunobiology; CD8+ T cells; CD4+ T cells; Need for APC costimulation for T-cell activation; The cytokine milieu and Th-cell polarization; T-cell plasticity; B-cell immunobiology; B-cell activation; The complement system; Cytokines; Structural features and categories (families) of cytokines; The importance of cytokines; Synergistic and antagonistic interactions; Stimulatory and inhibitory properties of cytokines

Redundancy and pleiotropyImmunological tolerance; T-cell central tolerance; T-cell peripheral tolerance; B-cell central tolerance; B-cell peripheral tolerance; Immunological memory; T-cell memory; B-cell memory; Summary; Acknowledgments; References; CHAPTER 3: Transplant Antigens: A Brief History of HLA; Introduction; Early investigations; HLA and disease; HLA and transplantation; HLA antibodies; Summary; References; CHAPTER 4: Transplant Antigen Biology; Introduction; Genetics of the major histocompatibility complex (MHC); MHC class I; MHC class II; MHC class III; Nature of HLA polymorphism

Human diversity in HLA repertoireHLA nomenclature; HLA epitopes and the structural basis of cross-reactivity; Structure and function of HLA molecules; HLA class I molecular structure; HLA class II molecular structure; Structural basis of peptide binding to HLA class I and class II molecules; Antigen processing and presentation; Differential expression of HLA class I and class II molecules; HLA Class Ib molecules; HLA-mediated signal transduction; Killer cell immunoglobulin-like receptors (KIR); Non-HLA transplant antigens; Anti-MICA antibodies; Summary; Acknowledgments; References

CHAPTER 5: Cellular Mechanisms of Adaptive ImmunityIntroduction; T-cell recognition of alloantigens: Direct, semidirect, and indirect presentation; Structural recognition of alloantigens by the TCR; T-cell costimulation and differentiation; Innate immune signals that influence T-cell responses; Where are T cells primed after transplantation?; Effector phase of the alloimmune response: T cells go to the graft; Effector T cells: Th1, Th2, Th17, and cytotoxic T cells; Therapeutic implications; Summary; Acknowledgments; References; CHAPTER 6: Humoral Mechanisms of Adaptive Immunity; Introduction

Antibodies

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-118-87343-2

1-118-88962-2

OCLC:

885020630