Inorganic chemical biology : principles, techniques and (applications) / edited by Gilles Gasser.

Format:

Book

Contributor:

Gasser, Gilles, editor.

Language:

English

Subjects (All):

Metals.

Chemistry, Inorganic.

Physical Description:

1 online resource (409 p.)

Edition:

1st ed.

Place of Publication:

Chichester, England : Wiley, 2014.

Summary:

Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.

Contents:

New applications of immobilized metal ion affinity chromatography in chemical biology / Rachel Codd, Jiesi Gu, Najwa Ejje, Tulip Lifa

Metal complexes as tools for structural biology / Michael D. Lee, Bim Graham and James D. Swarbrick

AAS, XRF and MS methods in chemical biology of metal complexes / Ingo Ott, Christophe Biot and Christian Hartinger

Metal complexes for cell and organism imaging / Kenneth Yin Zhang and Kenneth Kam-Wing Lo

Cellular imaging with metal carbonyl complexes / Luca Quaroni and Fabio Zobi

Probing DNA using metal complexes / Lionel Marclis, Willem Vanderlinden, Andre Kirsch De Mesmaeker

Visualization of proteins and cells using dithiol-reactive metal complexes / Danielle Park, Ivan Ho Shon, Minh Hua, Vivien M. Chen, Philip J. Hogg

Detection of metal ions, anions and small molecules using metal complexes / Qin Wang and Katherine J. Franz

Photo-release of metal ions in living cells / Celina Gwizdala and Shawn C. Burdette

Release of bioactive molecules using metal complexes / Peter Simpson and Ulrich Schatzschneider

Metal complexes as enzyme inhibitors and catalysts in living cells / Julien Furrer, Gregory S. Smith and Bruno Therrien

Other applications of metal complexes in chemical biology / Tanmaya Joshi, Malay Patra and Gilles Gasser.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781118684153

111868415X

9781118684252

1118684257

9781118682975

1118682971

OCLC:

865452431