Diabetes mellitus : a fundamental and clinical text / Derek LeRoith, Simeon I. Taylor, Jerrold M. Olefsky, editors ; Brian Brown, acquisitions editor ; Erin McMullan, developmental editor ; Steven P. Martin, supervising editor ; contributors E. Dale Abel [and six others].

Format:

Book

Contributor:

LeRoith, Derek, editor.

Taylor, Simeon I., editor.

Olefsky, Jerrold M., editor.

Brown, Brian, editor.

McMullan, Erin, editor.

Martin, Steven P., editor.

Abel, E. D. (E. Dale), contributor.

Language:

English

Subjects (All):

Diabetes.

Physical Description:

1 online resource (1566 pages) : illustrations (some color)

Edition:

Third edition.

Place of Publication:

Philadelphia, Pennsylvania : Lippincott Williams & Wilkins, 2004.

Summary:

Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.

Contents:

Cover

Copyright

Editors

Preface

Contents

Part I - Insulin Secretion

1 - The Two Phases of Glucose-Stimulated Insulin Secretion Mechanisms and Controls

2 - Insulin Gene Regulation

3 - Processing of the Insulin Molecule

4 - Electrophysiology of the Pancreatic β-Cell

5 - Sulfonylurea Receptors, Adenosine triphosphate-Sensitive Potassium Channels, and Insulin Secretion

6 - Insulinotropic Glucagon-Like Peptides

7 - Detrimental Effects of Chronic Hyperglycemia on the Pancreatic β-Cell

8 - Glucose Toxicity of the β-Cell Cellular and Molecular Mechanisms

9 - Lipotoxicity

10 - Islet Amyloid in Type 2 Diabetes

Part II - Insulin Action

11 - Physiologic Action of Insulin

12 - Integration of Biochemical and Physiologic Effects of Insulin on the Control of Blood Glucose Concentrations

13 - Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia

14 - The Role of Insulin Receptor Substrate Proteins in Insulin Signaling and Metabolic Regulation

15 - The Insulin Signaling Network and Insulin Action

16 - Knockout Mice as a Tool to the Understanding of Diabetes Mellitus

17 - Regulation of Insulin Action by Protein-Tyrosine Phosphatases

18 - Small GTPAses and Serine/Threonine Protein Kinase Cascades in Insulin Signal Transduction

19 - Protein Kinase C

20 - Regulation of Glycogen Synthesis

21 - Insulin Action on Glucose Transport

22 - Cellular and Molecular Processes Regulating Glucose Transporter 4 Translocation

23 - Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes

24 - Role for Phosphodiesterase 3B in Regulation of Lipolysis and Insulin Secretion

25 - Gene Regulation

26 - Insulin Degradation

27 - Insulin and the Ras-Dependent Signaling Pathway.

28 - Germline Manipulation of Glucose Transport and Glucose Homeostasis

29 - Molecular Links Between Peroxisome Proliferator-Activated Receptor-γ and Metabolic Disease

Part III - Definition and Classification

30 - Definition and Classification of Diabetes Mellitus and the Criteria for Diagnosis

Part IV - Type 1 Diabetes Mellitus

31 - The Natural History of Autoimmunity in Type 1A Diabetes Mellitus

32 - Genetics of Type 1 Diabetes

33 - Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus

34 - Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus

35 - Major Histocompatibility Locus and Other Genes that Determine the Risk for Development of Type 1 Diabetes Mellitus

36 - Associations Between Immune-Mediated (Type 1) Diabetes and Other Autoimmune Diseases

37 - Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus

38 - Animal Models of Autoimmune Diabetes Mellitus

39 - Insights from Transgenic and Gene Targeting Strategies in Type 1 Diabetes

40 - Diabetic Ketoacidosis and the Hyperglycemic Hyperosmolar Syndrome

Part V - Therapeutics for Type 1 Diabetes Mellitus

41 - Application of the Diabetes Control and Complications Trial

42 - Diet Therapy in Type 1 Diabetes Mellitus

43 - Exercise for the Patient with Type 1 Diabetes Mellitus

44 - Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus

45 - Immune Intervention

46 - Islet Cell Transplantation

47 - Islet Transplantation

48 - Pancreas Transplantation

49 - Gene Therapy for Metabolic Disease

50 - Surrogate β-cells for Insulin Replacement Therapy

51 - Stem Cells

Part VI - Type 2 Diabetes Mellitus

52 - Epidemiology of Type 2 Diabetes Mellitus

53 - Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus.

54 - Noninvasive Imaging of Insulin Action and Resistance in Humans

55 - Genetics of Human Obesity

56 - Obesity: Treatment

57 - Obesity in Type 2 Diabetes Mellitus

58 - Effects of Aging on Glucose Homeostasis

59 - Drug-Induced Diabetes Mellitus

60 - Insulin Secretion in Type 2 Diabetes Mellitus

61 - Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and the Insulin Resistance Syndrome

62 - Glucose Transporters and Pathophysiologic States

63 - Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action

64 - Inflammation, Tumor Necrosis Factor-α, and Insulin Resistance

65 - Adipokines: Regulators of Metabolic Integration and Energy Metabolism

66 - Fatty Acids and Insulin Resistance

67 - Triglyceride in Muscle

68 - Candidate Genes for Type 2 Diabetes Mellitus

69 - Genetic Syndromes Associated with Severe Insulin Resistance: Mutations in the Insulin Receptor Gene and Lipoatrophic Diabetes

70 - Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus

71 - Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus

72 - Primate Animal Models of Type 2 Diabetes

Part VII - Therapeutics for Type 2 Diabetes Mellitus

73 - Preventing Type 2 Diabetes: The Diabetes Prevention Program

74 - Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load

75 - Exercise in Patients with Type 2 Diabetes Mellitus

76 - Insulin Secretagogues: Sulfonylureas, Meglitinides, and Phenylalanine Derivatives

77 - Metformin

78 - Peroxisome Proliferator-Activated Receptor Modulators

79 - &amp

alpha

-Glucosidase Inhibitors in the Treatment of Diabetes

80 - Glinides

81 - Combination Therapy in Type 2 Diabetes Mellitus

82 - Intensive Insulin Therapy for Patients with Type 2 Diabetes

83 - Hypoglycemia in Type 2 Diabetes Mellitus.

84 - New Therapies to Promote Insulin Action

Part VIII - Pregnancy

85 - Intermediary Metabolism During Pregnancy: Implications for Diabetes Mellitus

86 - Effects of Maternal Diabetes Mellitus on Intrauterine Development

87 - Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications

88 - Gestational Diabetes Mellitus

Part IX - Descriptive and Clinical Complications

89 - Pathophysiology of Diabetic Retinopathy

90 - Pathogenesis of Diabetic Nephropathy

91 - Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment

92 - Diabetes Mellitus, Lipids, and Atherosclerosis

93 - Pathophysiology of Hypertension in Diabetes

94 - Macrovascular Complications of Diabetes Mellitus

95 - Skin and Diabetes

96 - Neonatal Diabetes Mellitus

97 - Hypoglycemia in the Adult

Part X - Mechanisms of Complications

98 - Biochemistry and Molecular Cell Biology of Diabetic Complications: A Unifying Mechanism

99 - Hyperinsulinemia and Insulin Resistance

100 - The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications

101 - Oxidative Stress, Inflammation, and Diabetic Complications

102 - Diabetic Vasculopathy

Color Plates

Index.

Notes:

Includes index.

Description based on print version record.

ISBN:

1-4511-6621-4

OCLC:

908511488