Angiogenesis : an integrative approach from science to medicine / edited by William D. Figg, Judah Folkman.

Format:

Book

Contributor:

Figg, William D.

Folkman, M. Judah.

Language:

English

Subjects (All):

Neovascularization.

Blood--Circulation.

Blood.

Physical Description:

1 online resource (616 p.)

Edition:

1st ed. 2008.

Place of Publication:

New York, NY : Springer, c2008.

Language Note:

English

Summary:

Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of research and has become the focus of scientists worldwide. Because of Folkman's discovery and research, the possibilities of antiangiogenic and angiogenic therapy have broadened beyond cancer to many noncancerous diseases. This book represents the first collection in a volume of which Dr. Folkman is co-editor. Dr. Folkman authored nearly 400 original papers and more than 100 book chapters. Dr. William Figg is the chief of the Molecular and Clinical Pharmacology Program at the National Cancer Institute, National Institutes of Health. Over the past 15 years, his laboratory and clinic at the NCI have focused on the development of angiogenesis inhibitors. Dr. Figg has published more than 380 publications.

Contents:

Physiological & Pathological Angiogenesis: Biology of the Angiogenic Process

History of Angiogenesis

Angiogenesis and Vascular Remodeling in Inflammation and Cancer: Biology and Architecture of the Vasculature

Endothelial Cell Activation

Pericytes, the Mural Cells of the Microvascular System

Matrix Metalloproteinases and Their Endogenous Inhibitors

Integrins in Angiogenesis

Angiogenesis and Regulatory Proteins

Fibroblast Growth Factor-2 in Angiogenesis

Vascular Permeability/Vascular Endothelial Growth Factor

Platelet-Derived Growth Factor

Angiopoietins and Tie Receptors

Basement Membrane Derived Inhibitors of Angiogenesis

Angiostatin and Endostatin: Angiogenesis Inhibitors in Blood and Stroma

Thrombospondins: Endogenous Inhibitors of Angiogenesis

Molecular & Cellular Mechanisms of the Angiogenic Process

Overview of Angiogenesis During Tumor Growth

Hypoxic Regulation of Angiogenesis by HIF-1

Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2

Nitric Oxide in Tumor Angiogenesis

VEGF Signal Tranduction in Angiogenesis

Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis

Immune Cells and Inflammatory Mediators as Regulators of Tumor Angiogenesis

Contribution of Endothelial Progenitor Cells to the Angiogenic Process

Tumor Angiogenesis and the Cancer Stem Cell Model

Targeting the Tumor Microenvironment (Stroma) for Treatment of Metastasis

Functional Assessments of Angiogenesis

Normalization of Tumor Vasculature and Microenvironment

Targeted Drug Delivery to the Tumor Neovasculature

Models for Angiogenesis

Surrogates for Clinical Development

Imaging of Angiogenesis

Tumor Endothelial Markers

Clinical Translation of Angiogenesis Inhibitors

Overview and Clinical Applications of VEGF-A

Protein Tyrosine Kinase Inhibitors as Antiangiogenic Agents

Therapeutic Strategies that Target the HIF System

The Clinical Utility of Bevacizumab

Development of Thalidomide and Its IMiD Derivatives

TNP-470: The Resurrection of the First Synthetic Angiogenesis Inhibitor

Clinical Development of VEGF Trap

Recent Advances in Angiogenesis Drug Development

Combination of Antiangiogenic Therapy with Other Anticancer Therapies

Immunotherapy of Angiogenesis with DNA Vaccines

Challenges of Antiangiogenic Therapy of Tumors

Pharmacogenetics of Antiangiogenic Therapy

Angiogenesis in Health & Disease

Angiogenesis in the Central Nervous System

Lymphatic Vascular System and Lymphangiogenesis

Ocular Neovascularization

Angiogenesis and Pathology in the Oral Cavity

Revascularization of Wounds: The Oxygen-Hypoxia Paradox

Journeys in Coronary Angiogenesis

Perspectives on the Future of Angiogenesis Research.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-37805-4

9786611378059

0-387-71518-5

OCLC:

272308574