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A handbook for DNA-encoded chemistry : theory and applications for exploring chemical space and drug discovery / edited by Robert A. Goodnow, Jr. ; contributors Raksha A. Acharya [and twenty five others].
- Format:
- Book
- Language:
- English
- Subjects (All):
- Combinatorial Chemistry Techniques--Methods.
- Combinatorial Chemistry Techniques.
- DNA--chemical synthesis.
- DNA.
- Drug Discovery--Methods.
- Drug Discovery.
- Gene Library--Small Molecule Libraries.
- Gene Library.
- Small Molecule Libraries--chemical synthesis.
- Small Molecule Libraries.
- Physical Description:
- 1 online resource (497 p.)
- Edition:
- 1st ed.
- Place of Publication:
- Hoboken, New Jersey : Wiley, 2014.
- Language Note:
- English
- Summary:
- This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable
- Contents:
- Just enough knowledge?
- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry
- A history of DNA-encoding
- DNA-compatible chemistry
- Foundations of a DNA-encoded library (DEL)
- Practices for synthesizing DNA-encoded libraries
- Chemical gene design for DNA-encoded libraries
- Analytical challenges for DNA-encoded library systems
- Information technology: functionality and architectures for DNA-encoding
- Theoretical considerations of the application of DNA-encoded libraries to drug discovery
- Begin with the end in mind : the hit-to-lead process
- Enumeration and visualization of large combinatorial chemical libraries
- Screening large compound collections
- Reported applications of DNA-encoded library chemistry
- Dual-pharmacophore DNA-encoded chemical libraries
- Hit identification and hit follow-up
- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding
- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches
- Keeping the promise? an outlook on dna chemical library technology.
- Notes:
- Description based upon print version of record.
- Includes bibliographical references at the end of each chapters and index.
- Description based on print version record.
- ISBN:
- 9781118832677
- 1118832671
- 9781118832738
- 1118832736
- 9781118832691
- 1118832698
- OCLC:
- 863127741
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