RNA structure and folding : biophysical techniques and prediction methods / edited by Dagmar Klostermeier, Christian Hammann.

Format:

Book

Contributor:

Hammann, Christian.

Klostermeier, Dagmar.

Language:

English

Subjects (All):

Protein folding.

RNA.

Physical Description:

1 online resource (432 p.)

Edition:

1st ed.

Place of Publication:

Berlin : Walter de Gruyter GmbH & Company, [2013]

Language Note:

English

System Details:

Mode of access: World Wide Web.

Summary:

While structure-function relationships of proteins have been studied for a long time, structural studies of RNA face additional challenges. Nevertheless, with the continuous discovery of novel RNA molecules with key cellular functions and of novel pathways and interaction networks, the need for structural information of RNA is still increasing. This volume provides an introduction into techniques to assess structure and folding of RNA. Each chapter explains the theoretical background of one technique, and illustrates possibilities and limitations in selected application examples.

Contents:

Frontmatter

Preface

List of contributing authors

Contents

1. Optical spectroscopy and calorimetry / Klostermeier, Dagmar / Hammann, Christian

2. Footprinting methods for mapping RNA-protein and RNA-RNA interactions / Duval, Mélodie / Romilly, Cedric / Helfer, Anne-Catherine / Fuchsbauer, Olivier / Romby, Pascale / Marzi, Stefano

3. Chemical approaches to the structural investigation of RNA in solution / Helm, Mark

4. Bioorthogonal modifications and cycloaddition reactions for RNA chemical biology / Höbartner, Claudia / Büttner, Lea / Javadi-Zarnaghi, Fatemeh

5. Analysis of RNA conformation using comparative gel electrophoresis / Lilley, David M. J.

6. Virus RNA structure deduced by combining X-ray diffraction and atomic force microscopy / McPherson, Alexander

7. Investigating RNA structure and folding with optical tweezers / Bercy, Mathilde / Mangeol, Pierre / Bizebard, Thierry / Tanner, N. Kyle / Banroques, Josette / Bockelmann, Ulrich

8. Fluorescence resonance energy transfer as a tool to investigate RNA structure and folding / Gubaev, Airat / Klostermeier, Dagmar

9. RNA studies by small angle X-ray scattering in solution / Kikhney, Alexey G. / Doniach, Sebastian / Svergun, Dmitri I.

10 Integrative structure-function analysis of large nucleoprotein complexes / Ménétret, Jean-François / Khatter, Heena / Simonetti, Angelita / Orlov, Igor / Myasnikov, Alexander G. / Venkatasubramanian, Srividhya Krishnagiri / Manicka, Sankar / Torchy, Morgan / Mohideen, Kareem / Humm, Anne-Sophie / Hazemann, Isabelle / Urzhumtsev, Alexandre / Klaholz, Bruno P.

11 Structure and conformational dynamics of RNA determined by pulsed EPR / Krstic, Ivan / Marko, Andriy / Grytz, Claudia M. / Endeward, Burkhard / Prisner, Thomas F.

12. NMR-based characterization of RNA structure and dynamics / Mozes, Christina R. / Hennig, Mirko

13. Crystallization of RNA for structure determination by X-ray crystallography / Ferré-D'Amaré, Adrian R.

14. RNA structure prediction / Steger, Gerhard / Giegerich, Robert

15. Analyzing, searching, and annotating recurrent RNA three-dimensional motifs / Petrov, Anton I. / Sweeney, Blake A. / Leontis, Neocles B.

Index

Notes:

Includes index.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed December 24, 2013).

ISBN:

9783110284959

3110284952

OCLC:

1002232145