The Wiley-Blackwell handbook of psychoneuroimmunology / edited by Alexander W. Kusnecov, Hymie Anisman.

Format:

Book

Contributor:

Anisman, Hymie.

Kusnecov, Alexander W.

Language:

English

Subjects (All):

Health.

Nervous system--Diseases--Immunological aspects.

Nervous system.

Psychoneuroimmunology.

Physical Description:

1 online resource (554 p.)

Edition:

1st ed.

Place of Publication:

Chichester, West Sussex ; Malden, Massachusetts : Wiley-Blackwell, 2014.

Language Note:

English

Summary:

This comprehensive resource details the history, methodology and development of research into psychoneuroimmunology, balancing it with meticulous coverage of both the clinical aspects and practical applications of the subject. A much-needed reference including overviews of key advances in the fieldDiscusses how psychoneuroimmunological research is conceived and executedIncludes contributions from a wealth of experts in the fieldForward by Robert Ader and Nicholas Cohen, founders of the disciplineAuthoritative and interdisciplinary in

Contents:

The Wiley-Blackwell Handbook of Psychoneuroimmunology; Contents; Preface; Foreword; List of Contributors; 1 Basic Principles in Immunology: Relevance for Studies in Psychoneuroimmunology; Introduction; The Components of the Immune System; Cytokines and chemokines - the immune system's messengers; The cells of the immune system; Modes of Immunity; The Immune System and the Brain; Methods in Immunology with Relevance for Psychoneuroimmunology; Lipopolysaccharides; Nucleic acids; Superantigens; Proteins; Cytokines; Live infectious agents

Immune Processes and their Clinical Consequences on Mental HealthConcluding Remarks; References; 2 Innervation of the Immune System; Basic Organization of the Autonomic and Sensory Systems; Overview of the ANS; Overview of the sensory system; Innervation of Lymphoid Organs; Bone marrow; Thymus; Spleen; Lymph nodes; Functional significance of sympathetic innervation in secondary lymphoid organs: lymph nodes and spleen; Innervation of Diffuse Lymphatic Tissue or Mucosa-Associated Lymphoid Tissue (MALT); No Parasympathetic Innervation of Immune Organs

The Role of the Vagus Nerve and the Cholinergic Anti-inflammatory ReflexSensory Innervation of Immune Organs; The Role of Sensory Nerves in Immune Regulation; Summary of Innervation of the Immune System; References; 3 In Vitro and In Vivo Assessment of Immune System Modulation of Brain Function and Neurochemistry; Overview; Approaches to Assessing Brain Changes Associated with Immune and Cytokine Challenges; Analysis of brain neurochemistry; Analysis of Neuron Function Alterations by Cytokines; Neuronal cell culture; Brain slices; In vivo recordings

What has electrophysiology told us about immune function and brain activity?Summary; Acknowledgments; References; 4 Control and Contributions of the Blood-Brain Barriers to Cytokine Levels in the CNS; Overview; The Blood-Brain Barrier; The Blood-Brain Barrier and the Immune Privileged CNS; Restrictive barrier function; The transport of cytokines across the BBB; Secretion of immunoactive substances by the BBBs; Other mechanisms by which the BBB could control brain cytokines; Conclusions; References; 5 The Immune-Neuroendocrine Network in Health and Disease; Introduction

Historical Perspective and Views: The Immune and Nervous System Talk to Each OtherCytokines Mediate a Resetting of the INE Network During Immune and Inflammatory Responses; Cytokines can take command of homeostasis during disease; The neuronal-cytokine network in the healthy brain; Pathophysiological Consequences of Alterations in the INE Network; Disruption of immune-brain communication during autoimmune, lymphoproliferative, and inflammatory diseases; Deleterious Effects of the INE Network During Prolonged Infections: Pulmonary Tuberculosis as an Example; Conclusions and Proposal

Acknowledgements

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed December 2, 2013).

ISBN:

9781118314777

1118314778

9781118314814

1118314816

9781118314760

111831476X

OCLC:

862050211