Equilibria and kinetics of biological macromolecules / Jan Hermans, Barry Lentz.

Format:

Book

Author/Creator:

Hermans, Jan.

Contributor:

Lentz, Barry.

Language:

English

Subjects (All):

Biomedical materials.

Macromolecules.

Physical Description:

1 online resource (527 p.)

Place of Publication:

Hoboken, New Jersey : Wiley, 2014.

Summary:

Progressively builds a deep understanding of macromolecular behavior Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors addre

Contents:

Thermodynamics

Four basic quantum mechanical models of nuclear & electronic motion : a synopsis

Molecular structure and interactions

Water and the hydrophobic effect

The molecular partition function

System ensembles and partition functions

Sampling molecular systems with simulations

Binding equilibria

Thermodynamics of molecular interactions

Elements of statistical mechanics of liquids and solutions

Analysis of binding equilibria in terms of partition functions

Coupled equilibria

Allosteric function

Charged groups : binding of hydrogen ions, solvation and charge-charge interactions

Some elements of polymer physics

Helix-coil equilibria

Protein unfolding equilibria

Elasticity of biological materials

Kinetics

Kinetics of protein folding

Irreversible and stochastic processes.

Notes:

Includes index.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-118-73377-0

1-118-73363-0

1-118-73376-2

OCLC:

861559760