High-dose cancer therapy : pharmacology, hematopoietins, stem cells / editors, James O. Armitage, Karen H. Antman.

Format:

Book

Contributor:

Armitage, James O., 1946- editor.

Antman, Karen, editor.

Language:

English

Subjects (All):

Cancer--Chemotherapy.

Cancer.

Cancer--Chemotherapy--Complications--Prevention.

Drugs--Dosage.

Drugs.

Hematopoietic growth factors--Therapeutic use.

Hematopoietic growth factors.

Physical Description:

1 online resource (973 p.)

Edition:

Third edition.

Place of Publication:

Philadelphia, Pennsylvania : Lippincott Williams & Wilkins, 2000.

Language Note:

English

Summary:

The Third Edition of this comprehensive reference has been overhauled, with 28 of 50 chapters either completely updated or rewritten by new authors. This reflects the fact that this treatment modality is now the standard of care for a variety of cancers, including 10-20,000 cases/year of various forms of leukemia, multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma, lung cancer, ovarian cancer, etc. High dosage chemotherapy is now also used in advanced cases of breast cancer. It is now being done by private practitioners in most of the hospitals in the country from the community hospit

Contents:

Cover

Copyright

Dedication

Editors

Foreword to the First Edition

Preface

Contents

Section I Strategies for the Use of Agents at High Dose

1 Pharmacologic Strategies for High-Dose Therapy

2 Preclinical Models for High-Dose Therapy

3 Pharmacokinetics

4 What Is the Best Strategy for Autologous Hematopoietic Stem Cell Transplantation in Cancer

5 Strategies for the Use of Total-body Irradiation as Systemic Therapy in Hematologic Malignancies

6 Radioimmunotherapy

7 Immune Adjuvant Therapy Post High-Dose Therapy

8 A Health Policy Perspective on High-Dose Cancer Therapy: Cost, Effectiveness, and Cost-Effectiveness

9 Quality of Life after Bone Marrow Transplantation

10 Gene Therapy

Section II Reestablishing Hematopoiesis after Dose-Intensive Therapy Transplantation

11 The Hematopoietic Microenvironment

12 Hematologic Reconstitution after Allogeneic Hematopoietic Cell Transplantation

13 Allogeneic Cord Blood Hematopoietic Stem Cells Transplants in Malignancies

14 Bone Marrow Transplantation Using Unrelated Donors

15 Autologous Bone Marrow Transplantation

16 Reestablishing Hematopoiesis with Peripheral Stem Cells

17 Immunologic Reconstitution after High-Dose Chemoradiotherapy and Allogeneic or Autologous Bone Marrow or Peripheral Blood Hematopoietic Stem Cell Transplantation

Marrow Contamination

18 Minimal Disease: Detection and Significance

19 Negative and Positive Stem Cell Selection

20 Stem Cell In Vitro Purging for Autologous Transplantation

Growth Factors

21 Granulocyte-Macrophage Colony-Stimulating Factor

22 Recombinant Human Granulocyte Colony-Stimulating Factor Support of the Cancer Patient

23 Erythropoietin

24 The Biology and Clinical Use of Stem Cell Factor

25 Other Cytokines (IL-11, Thrombopoietin, flt-3 Ligand, and IL-3).

Section III Laboratory and Clinical Support for Dose-Intensive Therapy

26 The American Society of Clinical Oncology and American Society of Hematology Recommended Criteria for the Performance of Bone Marrow Transplantation

27 Nursing for Patients Receiving High-Dose Chemotherapy with Hematopoietic Rescue

28 Line Maintenance

29 Blood Bank Support for Patients Undergoing High-Dose Chemotherapy

30 Infectious Complications after High-Dose Chemotherapy

31 Pulmonary Complications

32 Hepatic Complications of Bone Marrow Transplantation

33 Cardiovascular System and High-Dose Therapy

34 Multiple Organ Dysfunction Syndrome

35 Dermatology

36 Genitourinary, Gastrointestinal, Endocrine, Nervous System, and Coagulation Complications

37 Gonadal Complications

Section IV Clinical Applications of High-Dose Therapy

38 High-Dose Therapy in Acute Myeloid Leukemia

39 High-Dose Therapy in Acute Lymphoblastic Leukemia

40 Chronic Myelogenous Leukemia

41 Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia

42 High-Dose Therapy in Multiple Myeloma

43 High-Dose Therapy for Hodgkin's Disease

44 High-Dose Therapy for the Treatment of Non-Hodgkin's Lymphoma

45 High-Dose Therapy in Burkitt's Lymphoma

46 High-Dose Chemotherapy in Patients with Germ Cell Cancer

47 Dose-Intensive Therapy for Breast Cancer

48 Lung Cancer

49 High-Dose Chemotherapy and Stem Cell Transplantation for Ovarian Cancer

50 High-Dose Therapy and Stem Cell Transplantation for Neuroblastoma and Other Pediatric Solid Tumors

51 Brain Tumors

52 Other Solid Tumors

Color Figures

Subject Index.

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-4698-7453-9

OCLC:

913799496