Stem cells research compendium Volume 1 / Prasad S. Koka, editor.

Format:

Book

Contributor:

Koka, Prasad S.

ebrary, Inc., Content Provider.

Series:

Stem cells research compendium ; 1

Language:

English

Subjects (All):

Stem cells.

Cells.

Physical Description:

1 online resource (455 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2008.

Language Note:

English

Summary:

As stem cells can be readily grown and transformed into specialised tissues such as muscles or nerves through cell culture, their use in medical therapies has been proposed. This book presents leading research from around the world in this field.

Contents:

Intro

Stem Cells Research Compendium Volume 1

Contents

Preface

Foreword: Stem Cells

Megakaryocytopoiesis: From Marrow Stem Cells to Circulating Platelets

Abstract

Development of Megakaryocytes

Megakaryocyte Differentiation and Maturation

Thrombocytopoiesis

Summary

Acknowledgments

References

A Novel Serum-Free Culture System for the Analysis of Human Hematopoietic Progenitor Cells

Introduction

Materials and Method

Results

Discussion

Potential of Bone Marrow Stromal Stem Cells to Repair Bone Defects and Fractures

Therapeutic Potential of BMSSC for Bone Regeneration

The Role of Biomaterials in Bone Repair

Therapeutic Potential of Genetically Modified BMSSC

Alternative Sources of MSC

Conclusion

Adult Neural Stem Cells and Cellular Therapy

Adult Neurogenesis and Neural Stem Cells

Adult Neural Stem Cells a Model of Choice for Cellular Therapy for CNS Diseases and Injuries

The Cardiogenic Potential of Mouse and Human Embryonic Stem Cells: Cognitive Research to Envision the Therapeutic Use of the Cells

Introduction: The Need for Stem Cell Therapies in Cardiology

Cardiac Potential of Embryonic Stem Cells

Transcriptional Regulation of ESC Cardiac Specification

Differences in Early Cardiac Development of Mouse and Primate Embryo

Prospective Research

Hemopoietic Stem Cells and Autoimmunity: Impaired Mechanisms of Thymic Selection or Genetic Predisposition?

Abbreviations

Embryogenesis of the Thymus

Cellular Composition of the Thymus.

Origin of Hemopoietic Stem Cells in the Thymus

The Role of Notch in T Cell Development

Studies of Thymic Function

Generation of T Cell Repertoire through Thymic Selection: Cellular and Molecular Events

Regulation of Thymocyte Egress

The Thymus and Autoimmunity: Previous Observations in Thymus-Deficient Mice

The Role of AIRE Protein in Protection against Autoimmunity

Regulatory T Cells and Autoimmunity

The Role of the Thymus in Autoimmunity: Perspectives for Future Research

Stem Cells in the Treatment of Autoimmunity

Concluding Remarks

Control of Tissue Regeneration through Oxygen Concentrations

How Cells Can Respond to the Local Oxygen Environment

Stem Cell Proliferation and Mobilization

Cellular Homing to Injured Tissue in Response to Oxygen

Cellular Differentiation in Response to Oxygen

Conclusions

Control of Thymocyte Proliferation and Thymus Organ Size by CDK Inhibitors P18INK4C and P27KIP1

Materials and Methods

Human Embryonic Stem Cell-Derived Cardiomyocytes: Therapeutic Potentials and Limitations

Pluripotent Embryonic Stem, Germ and Carcinoma Cells

Heart Disease and Motivation for Cell-Based Therapy

Cardiac Differentiation - Insights from Studies with Mouse ESCs

Selection of the Cardiac Lineage from Differentiated mESCs

Human vs Mouse ESCs: Similarities and Differences

Therapeutic Potential

Stem Cells in Aging: Influence of Ontogenic, Genetic and Environmental Factors

Embryonic Stem Cells During Aging: Regulation of Senescence

Genetics of Aging Models.

Role of the Microenvironment and Niches for Stem Cells During Aging

Changes Produced in Neural and Hematopoietic Niches by HIV Infection: Niche Pathology or Defective Ecotaxis

Mapping of Genes of Lifespan, Using RI, Stem Cells and Studies of Niches

Influence of Nutrition on the Decline of Immunity with Aging in Mice

MHC Genes in Aging

Concluding Remarks: Perspectives for Future Research in Aging

Stem Cells in Aging: Contribution of the Immune System

Early Models of T Lymphocyte Development

Current Studies of the Effects of Aging on Lymphocyte Development from Hemopoietic Stem Cell Progenitors

Biochemical Basis for Age-Related Developmental Changes in T Cells

The Role of Apoptosis in Aging

Contribution of the Thymic Microenvironment (Temporary Niche) to Aging

Approaches to Restore Thymic Function in Humans as Related to Aging, Autoimmunity and Aids

Thymic Function During Human Development

Analysis of the Thymic Output

Signaling by Immune Receptors in Aging and Autoimmunity

Roles of Niches, Cytokines, T, B and NK Cells

Future Perspectives for Stem Cell Research Related Immunology of Aging

Diminished Gene Expression in Human Mesenchymal Stem Cells by Mutation of Focal Adhesion Kinase Signalling

Results and Discussion

Stem Cells as Therapy for Cardiovascular Disease: Lost in Translation?

Cardiac Disease Amenable to Stem Cell Therapies

Acute Myocardial Infarction

Chronic Heart Failure

Animal Models of Infarction and Heart Failure

Induced Myocardial Infarction.

Models of Chronic Myocardial Ischemia and Critical Limb Ischemia

Stem Cell Types Suitable for Cardiovascular Therapy

Adult Bone Marrow Stem Cells

Circulating Stem Cells

Adult Skeletal Myoblasts

Adult Adipose Stem Cells

Embryonic Stem Cells

Clinical Trials - the Discrepancy with Preclinical Studies

Human Chimerism and Tetragametism: Relevance of Embryonic or/and Hematopoietic Stem Cells

Polymorphic DNA Markers

Chimerism

Hematopoietic Chimerism (Materno-Fetal)

Hematopoietic Chimerism (Fetomaternal)

Twins

Freemartins

Fusion of Embryos

Fusion of Embryos with Evidence of Hematopoietic Monoclonality

Mathematical Modeling of T Cell Differentiation from Hemopoietic Stem Cell Progenitors

Cellular and Molecular Interactins in the Course of Thymic Selection and the Generation of the T Cell Repertoire

Pathways of T Lymphocyte Development

Feedback Loops in T Lymphocyte Development

Model and Results

The Challenge - Modeling Lymphocyte Repertoire Development and Function

Future Directions

The Importance of Large Animal Models in Stem Cell Research

I. Benefits of Large Animal Models

II. Characterization of ES Cell Lines in Large Animals

III. Safety and Efficacy

IV. Adult Stem Cells

V. A Promising Future

VI. Conclusion

Hypoxia Expands Primitive Hematopoietic Progenitor Cells from Mouse Bone Marrow During In Vitro Culture and Preserves the Colony-Forming Ability

Cobblestone Area-Forming Cells

References.

A Versatile Method for Differentiation of Multiple Neuronal Subtypes from Mouse Embryonic Stem Cells

Signaling Pathways Involved in the Maintenance of Human Embryonic Stem Cells

1. LIF

2. bFGF

3. The Transforming Growth Factor (TGF) b Signaling

4. Wnt

5. Sphingosine-1-Phosphate (S1P) and Platelet-Derived Growth Factor (PDGF)

6. Neurotrophins

Chimeric SCID-hu Model as a Human Hematopoietic Stem Cell Host that Recapitulates the Effects of HIV-1 on Bone Marrow Progenitors in Infected Patients

SCID-hu Mice as a Model of Hematopoiesis in Human Bone Marrrow

Thrombocytopenia

Anemia and/or HIV-1 Infection of Red Blood Cells

Neutropenia

The Effects of Ex Vivo Expansion on the Differentiation of Umbilical Cord Blood-Derived CD34+ Cells

Index.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-60876-922-4