Stem cell therapeutics for cancer / edited by Khalid Shah.

Format:

Book

Contributor:

Shah, Khalid.

Language:

English

Subjects (All):

Cellular therapy.

Cell transplantation.

Cancer--Treatment.

Cancer.

Physical Description:

1 online resource (354 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, c2013.

Language Note:

English

Summary:

Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials

Contents:

Stem Cell Therapeutics for Cancer; Copyright; Contents; Contributors; Preface; Section 1 Introduction; Chapter 1 Stem Cell Sources and Their Potential for Cancer Therapeutics; Introduction; Adult Stem Cells; Prospects and Caveats on the Way to the Clinics; References; Section 2 Migration and Fate of Stem Cells; Chapter 2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural Precursor Cell Migration; Introduction; CXCR4; CXCR4 and NSC; Conclusion; References; Chapter 3 Tumor Tropism of Mesenchymal Stem Cells; Introduction; Homing of MSC to Tumors; GPCR in MSC Migration

Activation of MSC Migration by Cytokines and Growth FactorsRole of MMPs in MSC Migration; Crosstalk Between MMP-1/PAR-1 Axes with Other Signaling Pathway; Concluding Remarks; Acknowledgements; References; Section 3 Stem Cell Therapy in Brain Cancer; Chapter 4 Stem Cell-Mediated TRAIL Therapy for Highly Aggressive Brain Tumors; Introduction; Transplantation Route and Fate of Stem Cells; Genetic Modification of SC; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); Stem cell-mediated delivery of TRAIL; Stem Cell-Mediated Delivery of TRAIL in Clinically Relevant Mouse Tumor Models

Resistance to TRAIL and Combination TherapiesImaging of Death-Receptor Expression Levels Identifies Modulators of TRAIL Sensitivity; Combination of MS-275 and Stem Cell-Delivered TRAIL Reveals Efficacy in TRAIL-Resistant GBMs in Vivo; Conclusions and Perspectives; References; Chapter 5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade Brain Tumors; Introduction; Enzymes and Prodrugs in GDEPT for Cancer Treatment; Classification of Brain Tumors; Source of Mesenchymal Stem Cells for Therapeutic Use; Stem Cell-Mediated Prodrug Gene Therapy for Glioblastoma

Stem Cell-Driven Cytosine Deaminase/5-FC SystemStem Cell-Driven Herpes simplex virus Thymidine Kinase/Ganciclovir System; Stem Cell-Driven Rabbit Carboxylesterase/ CPT-11 System; Stem Cell-Driven Therapeutic Cytokines and Proapoptotic Genes; Conclusions; Acknowledgements; References; Chapter 6 Role of Naïve Cord Blood Stem Cells in Glioma Therapy; Introduction; Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells ( hUCBSC); Role of hUCBSC in Glioma Therapy; Future Insights on Cord Blood Stem Cell Therapy; Acknowledgements; References

Chapter 7 Stem Cell-Based Antiangiogenic Therapies for Brain TumorsIntroduction; Stem Cell-Based Antiangiogenic Therapies; Conclusions and Perspectives; References; Chapter 8 Treatment of Metastatic Neuroblastoma with Mesenchymal Stem Cell-Based Oncolytic Virotherapy; Neuroblastoma; Oncolytic Virotherapy; Mesenchymal Stem Cell and Oncolytic Virotherapy; Conclusions and Perspectives; References; Section 4 Stem Cell Therapy in Other Cancer Types; Chapter 9 Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast Cancer; Introduction; MSC in Cancer Cytotherapy; Characteristics of UCMSC

UCMSC in cancer therapy

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9781118660621

1118660625

9781118660423

1118660420

9781118660331

1118660331

OCLC:

855504053