Drug-drug interactions for therapeutic biologics / edited by Honghui Zhou, Bernd Meibohm.

Format:

Book

Contributor:

Zhou, Honghui.

Meibohm, Bernd.

Language:

English

Subjects (All):

Drug interactions.

Physical Description:

1 online resource (379 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, c2013.

Language Note:

English

Summary:

Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions.<

Contents:

Drug interactions for therapeutic proteins : a journey just beginning / Honghui Zhou, Bernd Meibohm

Pharmacokinetic and pharmacodynamic-based drug interactions for therapeutic proteins / Dan Lu ... [et al.]

Drug interaction assessment strategies : small molecules versus therapeutic proteins / Shannon Dallas ... [et al.]

Model-independent and modeling-based methods to assess drug-drug interactions for therapeutic proteins / Di Wu, Jeffrey Barrett

Utility of in vitro methods in drug-drug interaction assessment and prediction for therapeutic biologics / Theresa Nguyen, Narendra Kishnani, Raymond Evers

Use of animal models for projection of clinical drug-drug interactions for therapeutic proteins / Eugenia Kraynov, Martin E. Dowty

The "cocktail" approach and its utility in drug-drug interaction assessments for therapeutic proteins / Alexander Jetter, Uwe Fuhr

Logistic considerations in study design for biologic drug-drug interaction assessments / Min Zhu and Yu-Nien (Tom) Sun

Statistical considerations in assessing drug-drug interactions for therapeutic proteins / Chuanpu Hu and Honghui Zhou

FDA perspectives on therapeutic protein drug-drug interaction assessments / Hong Zhao ... [et al.]

Disease-drug-drug interaction assessments for tocilizumab : a monoclonal antibody against interleukin-6 receptor to treat patients with rheumatoid arthritis / Xuapang Zhang and Barbara J. Brennan

Drug-drug interactions for etamercept : a fusion protein / Joan Korth-Bradley

Drug interactions of cytokines and anti-cytokine therapeutic proteins / J. Greg Slatter L.C. Wienkers and Leslie J. Dickmann

Drug interactions for growth factors and hormones / Yow-Ming Wang, Tarundeep Kakkar

Drug-drug interactions for nucleic acid-based derivatires / Jan Wang and Hong Zhao.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9781118630143

1118630149

9781118630211

1118630211

OCLC:

823930429