Neural circuit development and function in the healthy and diseased brain / editors-in-chief, John L. R. Rubenstein, Pasko Rakic.

Format:

Book

Author/Creator:

Rubenstein, John.

Contributor:

Rakic, Pasko.

Language:

English

Subjects (All):

Neural circuitry.

Local Subjects:

Neural circuitry.

Physical Description:

1 online resource (849 p.)

Edition:

1st ed.

Place of Publication:

Burlington : Elsevier Science, 2013.

Language Note:

English

Summary:

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the n

Contents:

Front Cover; Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Healthy and Diseased Brain; Copyright; Editors-in-Chief; Section Editors; Contents; Contributors; Introduction to Comprehensive Developmental Neuroscience; Section I: Circuit Development; Chapter 1: The Form and Functions of Neural Circuits in the Olfactory Bulb; 1.1. Introduction; 1.2. Synaptic Organization of the Mammalian Olfactory Bulb; 1.2.1. Organization of Sensory Inputs; 1.2.2. Synaptic Processing Within Olfactory Bulb Microcircuits

1.2.2.1. Synaptic Transmission at the First Synapses1.2.2.2. The Dendrodendritic Synapse Provides the Major Source of Inhibitory Contact to Output Neurons; 1.2.3. Sensory Processing in the Output Layer; 1.2.4. Centrifugal Fibers from Higher Brain Structures Profusely Innervate the Olfactory Bulb; 1.3. Circuit Development: A Lesson from Adult Neurogenesis; 1.3.1. Neurogenesis of Sensory Neurons in the Adult Olfactory Epithelium; 1.3.2. Adult-Born Interneurons in the Olfactory Bulb; 1.4. Structural and Experience-Induced Plasticity in the Olfactory Bulb

1.4.1. Activity-Dependent Plasticity in the Olfactory Bulb: Cell Properties and Transmitters1.4.2. Adult-Born Neurons Are Substrates for Experience-Induced Plasticity; 1.5. Concluding Remarks; Acknowledgments; References; Chapter 2: Functional Circuit Development in the Auditory System; 2.1. Introduction to Auditory System Development; 2.1.1. A Neurobiological Approach to Studying Auditory System Development; 2.1.2. Basic Concepts of Cochlear Transduction; 2.1.3. Scope of this Chapter; 2.2. Development of Peripheral Circuits; 2.2.1. Developing Networks Within the Cochlea

2.2.2. Development of the Place Code2.2.3. Development of Afferent and Efferent Circuits; Phase 1: Well Before Hearing Onset; Phase 2: Shortly Before Hearing Onset; Phase 3: Shortly After Hearing Onset; 2.2.4. Conclusions; 2.3. Development of Brainstem Circuits; 2.3.1. Functional Circuit Assembly in the Brainstem; 2.3.2. Development of Fine-Scale Connectivity in the MSO; 2.3.3. Development of Fine-Scale Connectivity in the LSO; 2.3.4. Afferent Regulation of Cochlear Nucleus Development; 2.3.5. Afferent Regulation of 3rd-Order Brainstem Nuclei

2.3.6. Influence of the Source and Pattern of Afferent Activity on Brainstem Circuits2.3.7. Conclusions; 2.4. Development of Auditory Midbrain and Forebrain Circuits; 2.4.1. Development of Thalamocortical Subplate Circuitry; 2.4.2. Postnatal Development of Local Cortical Circuits; 2.4.3. Afferent Regulation of Higher Auditory Circuit Development; 2.4.4. Developmental Regulation over Reinstating Hearing in the Deaf; 2.4.5. Experience-Dependent Influences on Functional Circuit Development; 2.4.6. Conclusions and Directions for Future Research; References

Chapter 3: Development of the Superior Colliculus/Optic Tectum

Notes:

Description based upon print version of record.

ISBN:

9780123973467

0123973465

OCLC:

845254780