Genotoxicity : evaluation, testing and prediction / Andor Kocsis and Hajna Molnar, editors.

Format:

Book

Contributor:

Kocsis, Andor.

Molnar, Hajna.

Series:

Genetics--research and issues series.

Genetics--research and issues series

Language:

English

Subjects (All):

Genetic toxicology.

Physical Description:

1 online resource (377 p.)

Edition:

1st ed.

Place of Publication:

Hauppauge, N.Y. : Nova Science Publishers, c2009.

Language Note:

English

Summary:

This book looks at genotoxicity which is a deleterious action on cell genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogenic, specifically those capable of causing genetic mutation and of contributing to the development of tumors. In humans, DNA damage or genotoxicity may be caused by exposure to outside agents like radiation, pesticides, combustion of hydrocarbon products as well as antineoplastic drugs. DNA damage could also come from inside of the body, determined mainly by excessive free radical production generated by some disease process. The importance then, is to identify the genotoxity and try to protect the body, which may be as simple as removing the source of exposure or providing protection against such agents. This new important book gathers the latest research from around the globe in this dynamic field of study.

Contents:

The importance of the in vitro genotoxicity evaluation of food components : the selenium / Vanessa Valdiglesias ... [et al.]

In vitro high-throughput assays for assessment of genetic toxicology / Xuemei Liu ... [et al.]

Genotoxicity evaluation of exposure to lead / Julia García-Lestón ... [et al.]

Genotoxicity by micronucleus assay for medical devices development / Andrea Cecilia Dorion Rodas, Patricia Santos Lopes, Olda Zazuco Higa

Genotoxicity produced by disease and drugs / Guillermo M. Zúñiga-González ... [et al.]

Modification of chemical mutagenesis / A.D. Durnev ... [et al.]

Co-mutagenic effects of nifedipine and diltiazem in vivo / A.D. Durnev ... [et al.]

Usefulness of bulky DNA adduct formation as a biological marker of exposure to airborne particulate matter (Pm2.5) in in vitro cell lung models : a comparative study / Sylvain Billet ... [et al.]

Impact assessment and evaluation of cadmium-induced genotoxicity and clastogenicity in mice / Malay Chatterjee and Mary Chatterjee

Loss of heterozygosity and/or microsatellite instability in multiple critical regions of 3p and 9p chromosomes in human epithelial lung cells (L132) exposed to air pollution particulate matter (Pm2.5) / Françoise Saint-Georges

Prediction of the human radiosensitivity : what is the most relevant endpoint? : gene expressions, mutations, or functions? / Catherine Massart

Application of genotoxicity to dental materials research / Daniel Araki Ribeiro

Use of the comet assay to evaluate pesticide toxicity on non-target microalgae / Prado, R.

Numberless drugs are not adequately tested for the potential genotoxic-carcinogenic risk to humans / Giovanni Brambilla and Antonietta Martelli.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61728-426-2

OCLC:

841168965