Nutrigenomics : application to the development of nutraceuticals and cosmeceuticals / M.T. Ravi Subbiah, editor.

Format:

Book

Contributor:

Subbiah, M. T. Ravi.

Series:

Genetics--research and issues series.

Nutrition and diet research progress series.

Genetics--research and issues

Nutrition and diet research progress

Language:

English

Subjects (All):

Nutrition--Genetic aspects.

Nutrition.

Human genome.

Physical Description:

1 online resource (227 p.)

Edition:

1st ed.

Place of Publication:

Hauppauge, N.Y. : Nova Science Publishers, Inc., 2013.

Language Note:

English

Summary:

Nutrigenomics promises us the ability to tailor diet based on individual genetic make-up. Through the advances made in the Human Genome Project, single nucleotide polymorphisms in important genes have been identified and their clinical association with many metabolic imbalances has been documented. This has resulted in the creation of a nutrigenomic test panel that can be used to evaluate individual genomic differences in the clinical laboratory. The ability to interpret these nutrigenomic tests and perhaps recommend specific nutraceuticals and functional foods that can modify negative health effects of individual genetic profiles is the hallmark of nutrigenomics and can play a vital role in personalized medicine.

Contents:

Intro

NUTRIGENOMICS: APPLICATION TO THE DEVELOPMENT OF NUTRACEUTICALS AND COSMECEUTICALS

Library of Congress Cataloging-in-Publication Data

Contents

About the Editor

Introduction

Chapter I: Nutrigenomics and its Role in Personalized Medicine

References

Nutrigenomics and Nutraceutical Development

Chapter II: Definitions, Concepts and Application of Nutrigenomics in Health

Abstract

Definition of Nutritional Genomic Sub-Disciplines

Genes of Nutrigenetic Interest

Nutrigenomic Advances and Its Potential for Nutraceutical Development

Application of Nutrigenomics to Skin Health: Special Considerations

The Future of Nutrigenomics and Its Application in Personalized Medicine

Chapter III: Nutrigenomic Effects of Olive Oil on Cardiovascular Risk

Abbreviations

1. Mediterranean Diet and Cardiovascular Health

2. Molecular Mechanisms of the Beneficial Effect of Olive Oil Ingestion

3. Nutrigenomic Effects of Olive Oil Consumption on Cardiovascular Risk

3.1. Genes Related with Inflammation Processes

3.2. Cell Surface Expression Genes

3.3. Genes Related with Insulin Sensitivity

3.4. Hepatic Genetic Expression

Acknowledgments

Chapter IV: Dietary Mushrooms: An Excellent Source for Nutraceuticals Capable of Reducing Risk Factors for Cardiovascular Disease

Dietary Mushrooms and Nutraceuticals

Mushroom Bioactive Compounds and Mechanisms of Action

Hypocholesterolemic Effects

Inhibition of Vascular Adhesion Molecule Expression

Regression of Atherosclerotic Plaques

Anti-Inflammatory and Vascular Effects

Antioxidant Activity

Glucose Metabolism and Insulin Action.

Improvements in Blood Pressure

Applications in Modern Medicine and Dietary Supplements

Conclusion

Chapter V: Metabolic and Genetic Factors Responsible for Variable Inter-Individual Response of Blood Lipids to Nutraceutical Therapy

Lipid-Lowering Response to Nutraceuticals

Types of Variability

Variable Lipid Responses to Specific Dietary Bioactives

Cholesterol

Soy Protein and Isoflavones

Dietary Fiber

Omega 3 Fatty Acids

Plant Sterols

Chapter VI: Nutraceuticals to Prevent Thrombogenesis and Its Application to Women's Health

Factor V Leiden

Prothrombin 20210A

Hyperhomocysteinemia

Antithrombin Deficiency

Protein C and Protein S

Thrombosis and Its Significance in Women's Health

Potential of Guarana Components As Antithrombotic Nutraceuticals

Anti-Platelet Aggregation Effect of Guarana Seeds

Neutraceuticals Preventing Platelet Aggregation and Thrombosis

Antioxidants

Polyphenols

Other Componds

Nutrigenomics and Cosmeceutical Development

Chapter VII: Nutritional Genomics in Skin Health: Application to the Development of Nutriceuticals and Cosmeceuticals

Nutrigenomics and Nutrigenetics

Active Ingredients in Cosmeceuticals/Nutriceuticals

Pigment Lightening Agents

Peptides

Growth Factors

Botanicals

Chamomile and Aloe Vera

Retinoids

Nutritional Genomics and Cosmeceuticals/ Nutriceuticals

Challenges of Nutritional Genomics and Conclusion

Chapter VIII: Development of Nutraceuticals and Cosmeceuticals as Epigenetic Modulators in Skin Health Care

Chromatin States in the Epigenomic Landscape.

Controlling Immune Homeostasis in Skin Biology

From Enhanceosome to Histone Code

Dietary Phytochemicals As Multi-Functional Epigenetic Modulators

Inflammatory Skin Disorders and Epigenetic Reprogramming

Acknowledgment

Chapter IX: Use of Nanotechnology in the Development of Cosmeceuticals for Skin Health

1. Introduction

2. Definitions of Cosmeceuticals and Skin Nutraceuticals

2.1. Cosmeceuticals

2.2. Skin Nutraceuticals

3. Lipid Nanocarriers

3.1. Cosmetic Nanoemulsions and Microemulsions

3.2. Cosmetic Lipid Nanoparticles (SLN, NLC)

4. Nutraceutical Nanocarriers for Skin Health in Marketed Formulations

Newer Targets and Sources for Nutraceutical Development

Chapter X: Membrane Targets in Nutraceutical Development

1. The Complexity of Membrane Organization

2. Lipid Rafts and Caveolae Are Specialized Domains in Membranes throughout the Cell

2.A. Lipid Rafts Are Found in Apical, Lateral and Basal Surfaces and within Multiple Organelles throughout the Cell Interior

2.B. Proteins Associated with Caveolae and Lipid Rafts Confer Stability and Serve a Major Scaffolding Role

3. Lipid Raft Associated Complexes on the Cell Surface Define Novel Organization and Specialized Functions

4. Whole Cell Homeostasis of Lipid Rafts,Caveolae and Associated Intracellular Pathways

5. Caveolae, Lipid Rafts, and Nutraceutical Development

5.A. Whole Cell Homeostasis Defines Novel Targets for Modulation of ROS and RNS Activity

5.B. Modulation of Lipid Raft Homeostasis in Prostate Cancer: Targeting Oxidative Stress to Restore Normal Regulation

5.C. Nutraceutical Targeting of Vascular Dysfunction, Endothelial Injury/ Repair and Angiogenesis

5.D.

References.

Chapter XI: Lepidium Meyenii (Maca):Excellent Source for Nutrigenomic Exploration and the Developmentof Nutraceuticals for Fertility and Sexual Health

Historical Aspects

Biology

Chemistry

Primary Metabolites

Secondary Metabolites

Experimental Studies

Studies in Humans

Maca and Sexual Function

Maca and Sperm Function

Maca As Energizer

Maca and Metabolic Syndrome

Maca and Osteoarthritis

Toxicity

Bioethical and Educational Issues in Nutrigenomics

Chapter XII: Application of Nutrigenomics in Personalized Nutrition: Other Critical Issues

Direct-to-consumer Genetics (DTCG)

Bio-Ethical Issues

Nutrigenomic Education and Professional Training

Index.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-62417-075-7

OCLC:

839695500